In UPSTAIRS, methods and open-access algorithms will be created, to facilitate the use of powerful contemporary separation technology for other (industrial) disciplines. By automating the selection and simultaneous optimization of a large number of parameters, contemporary methods can be drastically improved. This will help society solve pressing problems and will help us better understand materials, art, pharmaceuticals, environment, and other matrices.

Advanced materials are of essential importance throughout society. Modern plastics such as nanoparticles and nanoplastics are, however, controversial, due to potential dangers for health and environment. In the STREAMLINED-project, manufacturing companies (BASF, Covestro, Dow and IFF), instrument manufacturers (GL Sciences and Postnova), research institutes (TNO and Het Waterlaboratorium), and knowledge institutes (University of Amsterdam and Vrije Universiteit Amsterdam) work together to address this challenge with other stakeholders (such as RIVM, Ardena and Horiba) by developing a key technology that will allow manufacturers to innovate their materials, and regulatory bodies to design meaningful policies.

Light affects many materials used in e.g. pharmaceuticals, paints and art objects impacting their functional, health-related, and/or aesthetic properties. Studying light-induced degradation (LID) is highly challenging, especially in heterogeneous materials. Current LID evaluation methods are time-consuming, error-prone, and often yield insufficient chemical insights. ConSOLIDATe seeks to enhance our comprehension of LID across various relevant materials, including the influence of factors like temperature, humidity, oxygen, and additives. Advanced light-irradiation, separation, spectroscopic and computational techniques will be developed to help elucidate degradation pathways in solution and solid phase and assess the extent of correlation between these processes.

Immunoglobulines behoren tot de belangrijkste moleculen van het immuunsysteem en bestaan in talloze varianten. Het HYPE-IMMUNe-project heeft tot doel workflows te ontwikkelen die zijn gebaseerd op scheidingen en affiniteit in combinatie met massaspectrometrie. Daarmee kunnen de structuur-functierelaties van de immunoglobulines die verantwoordelijk zijn voor de respons op een ziekte of een auto-immuunrespons worden opgehelderd. Deze technologie is grensverleggend voor de ontwikkeling van nieuwe biotherapeutica en voor vroege diagnoses.