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Addenbrooke's Hospital

Addenbrooke's Hospital

3 Projects, page 1 of 1
  • Funder: UK Research and Innovation Project Code: EP/V036777/1
    Funder Contribution: 1,357,110 GBP

    This project brings together unique expertise in Computational and Experimental Fluid Dynamics, Model Reduction and Artificial Intelligence, to identify solutions for the management of people and spaces in the current pandemic and post lockdown. A new interactive tool is proposed that evaluates the risk of infection in the indoor environment from droplets and aerosols generated when breathing, talking, coughing and sneezing. This capability will become more critical as winter approaches and building ventilation will need to be limited for comfort considerations. The fluid dynamic behaviour of droplets and aerosols, the effect of using face masks as well as other parameters such as room volume, ventilation and number of occupants are considered. A datahub capable of storing, curating and managing heterogeneous data from sources internal and external to the project will be created. A synergetic experimental and numerical approach will be undertaken. These will complement the existing literature and data from other EPSRC-funded projects providing suitable datasets with adequate resolution in time and space for all the relevant features. To support experiments and numerical simulations, reduced order models capable of interpolating and extrapolating the scenarios collected in the database will be used. This will permit the estimation of droplet and aerosol concentrations and distributions in unknown scenarios at low-computational cost, in near real-time. A state-of-the-art AI-based framework, incorporating descriptive, predictive and prescriptive techniques will extract the knowledge from the data and drive the decision-making process and provide in near real-time the assessment of risk levels.

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  • Funder: UK Research and Innovation Project Code: EP/W026899/2
    Funder Contribution: 5,761,840 GBP

    Nuclear technology is, by definition, based around the principle of subatomic physics and the interaction of radiation particles with materials. Whilst the microscopic behaviour of such systems is well understood, the degree of inhomogeneity involved means that the ability to predict the flux of particles through complex physical environments on the macroscopic (human) scale is a significant challenge. This lies at the heart of how we design, regulate and operate some of the most important technologies for the twenty-first century. This includes building new reactors (fission and fusion), decommissioning old ones, medical radiation therapy, as well as opening the way forward into space technologies through e.g. the development of space-bound mini-reactors for off-world bases and protection for high-tech equipment exposed to high-energy radiation such as satellites and spacesuits. Accurate prediction of how radiation interacts with surrounding matter is based on modelling through the so-called Boltzmann transport equation (BTE). Many of the existing methods used in this field date back decades and rely on principles of simulated (e.g. neutron) particle counting obtained by Monte Carlo and other numerical methods. Input from the mathematical sciences community since the 1980s has been limited. In the meantime, various mathematical theories have since emerged that present the opportunity for entirely new approaches. Together with powerful modern HPC and smarter algorithms, they have the capacity to handle significantly more complex scenarios e.g. time dependence, rare-event sampling and variance reduction as well as multi-physics modelling. This five-year interdisciplinary programme of research will combine modern mathematical methods from probability theory, advanced Monte Carlo methods and inverse problems to develop novel approaches to the theory and application of radiation transport. We will pursue an interactive exploration of foundational, translational and application-driven research; developing predictive models with quantifiable accuracy and software prototypes, ready for real-world implementation in the energy, healthcare and space nuclear industries. This programme grant will unite complementary research groups from mathematics, engineering and medical physics, leading to sustained critical mass in academic knowledge and expertise. Through a diverse team of researchers, we will lead advances in radiation modelling that are disruptive to the current paradigm, ensuring that the UK is at the forefront of the 21st century nuclear industry.

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  • Funder: UK Research and Innovation Project Code: EP/W026899/1
    Funder Contribution: 6,001,430 GBP

    Nuclear technology is, by definition, based around the principle of subatomic physics and the interaction of radiation particles with materials. Whilst the microscopic behaviour of such systems is well understood, the degree of inhomogeneity involved means that the ability to predict the flux of particles through complex physical environments on the macroscopic (human) scale is a significant challenge. This lies at the heart of how we design, regulate and operate some of the most important technologies for the twenty-first century. This includes building new reactors (fission and fusion), decommissioning old ones, medical radiation therapy, as well as opening the way forward into space technologies through e.g. the development of space-bound mini-reactors for off-world bases and protection for high-tech equipment exposed to high-energy radiation such as satellites and spacesuits. Accurate prediction of how radiation interacts with surrounding matter is based on modelling through the so-called Boltzmann transport equation (BTE). Many of the existing methods used in this field date back decades and rely on principles of simulated (e.g. neutron) particle counting obtained by Monte Carlo and other numerical methods. Input from the mathematical sciences community since the 1980s has been limited. In the meantime, various mathematical theories have since emerged that present the opportunity for entirely new approaches. Together with powerful modern HPC and smarter algorithms, they have the capacity to handle significantly more complex scenarios e.g. time dependence, rare-event sampling and variance reduction as well as multi-physics modelling. This five-year interdisciplinary programme of research will combine modern mathematical methods from probability theory, advanced Monte Carlo methods and inverse problems to develop novel approaches to the theory and application of radiation transport. We will pursue an interactive exploration of foundational, translational and application-driven research; developing predictive models with quantifiable accuracy and software prototypes, ready for real-world implementation in the energy, healthcare and space nuclear industries. This programme grant will unite complementary research groups from mathematics, engineering and medical physics, leading to sustained critical mass in academic knowledge and expertise. Through a diverse team of researchers, we will lead advances in radiation modelling that are disruptive to the current paradigm, ensuring that the UK is at the forefront of the 21st century nuclear industry.

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