The number of people worldwide living with dementia and cognitive impairment is increasing, mainly due to people living longer, so we want to figure out how where we live affects dementia and brain health as we get older. Some research suggests that where we live might influence our brain health. For example, poor air quality in towns and cities, can lead to a decline in brain health. As more of us now live in towns and cities, it is important that the environment where we live is scientifically designed and improved to maximise our brain health. The complex social and physical environments where we live make some people more vulnerable than others to developing cognitive impairment. In other words, the factors that account for who is most likely to develop cognitive ill-health due to the environment has less to do with 'how' we live and more to do with 'where' we live. We do not know how these factors interact to make urban environments a problem for brain health, nor which are the best policies and interventions for promoting healthy ageing and brain health for our poorest communities. Our project will provide evidence for policies and practices that provide supportive urban environments to promote healthy ageing, including promoting brain health. This could include using creative urban designs to support people to adopt and maintain healthier lifestyles such as being more active. However, this needs a strong evidence base with expert community advocates who can articulate how supportive urban environments can improve brain health. Our research has the following steps: 1. First, with the help of stakeholders, including those from business, industry, and local government, and a review of existing research, we will represent the relationships between our biology, our lifestyles and our environment in a diagram illustrating how they likely interact to affect brain health, because visual thinking can help stakeholders better identify possible intervention sweet-spots to improve brain health. 2. By analysing data from over 8,000 older people in Northern Ireland, and linking this to information about where they live, such as the amount of air pollution, the toxins in soil, or how walkable their neighbourhoods are, we will explore how different environmental factors relate to brain health. 3. Next, we will collect new data on a subgroup of 1,000 older people including more in-depth measures of brain health and better measures of physical activity, using GPS devices worn around the waist that monitor our locations. This will allow us to explore how the urban environment influences our brain health. 4. Then, we will explore how aspects of our biology play a role in how the urban environment affects our brain health. 5. We will host workshops with local citizens to 'sense-check' our findings and co-develop promising prevention approaches. In these, we will explore the acceptability, affordability, feasibility and sustainability of new initiatives to improve the environmental influences on brain health. This might include, for example, policies on: expanding the car-free areas of the city to reduce air pollution; increasing the number of footpaths and cycle paths to encourage walking and cycling; improving public transport to reduce car use. As a result of our research we will produce: 1. A map of the system in which our genes, lifestyle behaviours and urban environments interact to affect brain health, to help guide stakeholders towards policies and programmes that can improve brain health. 2. An evidence base exploring how where we live affects our brain health. 3. A suite of potential policies and interventions to improve brain health and promote healthy ageing 'tested' (in terms of acceptability and feasibility) with older people, business, industry, policymakers and other stakeholders.

The decarbonisation of industrial clusters is of critical importance to the UK's ambitions of cutting greenhouse gas emissions to net zero by 2050. The UK Industrial Decarbonisation Challenge (IDC) of the Industrial Strategy Challenge Fund (ISCF) aims to establish the world's first net-zero carbon industrial cluster by 2040 and at least one low-carbon cluster by 2030. The Industrial Decarbonisation Research and Innovation Centre (IDRIC) has been formed to support this Challenge through funding a multidisciplinary research and innovation centre, which currently does not exist at the scale, to accelerate decarbonisation of industrial clusters. IDRIC works with academia, industry, government and other stakeholders to deliver the multidisciplinary research and innovation agenda needed to decarbonise the UK's industrial clusters. IDRIC's research and innovation programme is delivered through a range of activities that enable industry-led, multidisciplinary research in cross-cutting areas of technology, policy, economics and regulation. IDRIC connects and empowers the UK industrial decarbonisation community to deliver an impactful innovation hub for industrial decarbonisation. The establishment of IDRIC as the "one stop shop" for research and innovation, as well as knowledge exchange, regulation, policy and key skills will be beneficial across the industry sectors and clusters. In summary, IDRIC will connect stakeholders, inspire and deliver innovation and maximise impact to help the UK industrial clusters to grow our existing energy intensive industrial sectors, and to attract new, advanced manufacturing industries of the future.

The UK uses around 50 GW of energy to heat and cool buildings with only 6% delivered from renewable sources. Heating of buildings represents almost a quarter of UK carbon emissions, while demand for cooling is projected to increase as the climate warms and summers become hotter. The UK Heat and Buildings Strategy is clear that action to reduce emissions is required now to facilitate compliance with legally binding 2050 Net Zero targets. Moreover, the current geopolitical uncertainty has highlighted the risks associated with importing energy. However, heat is challenging to decarbonise due to its extreme seasonality. Daily heat demand ranges from around 15 to 150 GW, so new green technologies for inter-seasonal storage are essential. Geothermal resources offer natural heat energy, very large-scale seasonal energy storage, cooling as well as heating, and steady, low carbon energy supply. Widespread exploitation of urban geothermal resources could deliver a significant component - and in some cases all - of the UK's heating and cooling demand, supporting UK self-sufficiency and energy security. However, barriers remain to uptake of geothermal energy, especially at large-scale in urban areas. There is uncertainty in the size of the underground resource, the long-term sustainability of urban geothermal deployments, and potential environmental impacts. New methods and tools are required to monitor and manage installations to ensure the resource is responsibly used. These knowledge gaps, along with lack of awareness and guidance available for stakeholders and decision makers, result in higher than necessary risks and therefore costs. In this project, we will remove obstacles to uptake by reducing uncertainty about how the ground behaves when used to store and produce heat and cool at a large scale in urban areas. We will focus on relatively shallow (<400m depth) geothermal resources and open-loop systems in which groundwater is pumped into and out of porous, permeable aquifer rocks underground, because these offer large storage capacity and can deliver heat and cool. Shallow, open-loop systems are also deployable in most UK urban areas and have lower investment costs than technologies which require deeper drilling. We will conduct advanced field experiments with state-of-the-art monitoring, supported by laboratory experiments, to determine the response of aquifers to storage and exploitation of heat and use the results to understand how temperature changes over a wide area as groundwater flow transfers heat within the aquifer. We will compare two different aquifers, with contrasting types of underground flow regimes, that can be exploited across much of the UK. We will also determine how temperature changes impact groundwater quality and stress ecological environments and sensitive receptors, as well as understand any risks of ground movement caused by use of the resource. The field data will be used to create calibrated heat flow models, which we can use as a 'numerical laboratory' to simulate and explore the capacity of urban geothermal and how different installations within a city might interact. The results will support planning of future resource use and assess the capacity of geothermal resources to store waste heat from industrial processes and commercial buildings and return it later when needed. We will explore the use of AI-based models that can 'learn' from data provided by geothermal operators to actively manage the resource in a responsible and integrated way. Together, this research will permit regulators to plan and permit installations to ensure fairness and prevent environmental damage, as well as ensuring system designs realistically predict the amount of energy available. Recommendations will be made for resource assessment, safe and sustainable operation and management, to stimulate the widespread development of low carbon, geothermally heated and cooled cities.