Subduction zones are a key valve mediating global S processing and the climatic effects of arc volcanism, the economic potential of arc magmas, and the oxidation state of solid Earth reservoirs. Yet, the inputs, processing and recycling of S throughout the subduction system are still inaccurately known. This international project targets major unknowns in the sulfur cycle at subduction zones. The US-NSF focus of this project (PI Plank, LDEO) will fill a key knowledge gap in terms of S inputs to the mantle at subduction zones. It will involve extensive analysis of sedimentary sections at the Tonga, Marianas, Aleutians, Alaska and Central America trenches, chosen to represent end-member oceanic environments for sulfur deposition and diagenesis and extreme isotopic variations. Ocean Drilling Programs cores will be analyzed by XRF core scanning, a strategic approach to quantify heterogeneously disseminated pyrite and barite, major hosts of sulfur in sediment. Core scanning results will guide discrete sampling for bulk sulfur and sulfur isotope analyses at the University of Palermo, in collaboration with Prof. Aiuppa and Vizzini. Pilot data collected in Palermo demonstrate the quality of the coupled Elemental Analyzer-Mass Spectrometry technique and the clear sulfide- vs. sulfate-dominated regimes that may occur in a single sedimentary section. The outcome will be the first comprehensive estimates (with uncertainties) for the fluxes and isotopic compositions of S into end-member trenches and improved global estimates. The UK-NERC part of this project (PI Mather, Oxford) will take a novel approach to understanding volcanic arc S outputs. It will measure for the first time the sulfur isotopic composition in undegassed olivine-hosted arc melt inclusions. Pilot data collected at NERC Ion Microprobe Facility at Edinburgh demonstrate the viability of the technique, and yield positive delta(34)S in melt inclusions from Fuego volcano. Planned work will include well-studied melt inclusions suites from the same subducting systems as the sediment targets (above). This will ensure close collaboration between the US and UK parts of this project, and allow for the first-time direct tracing of sulfur isotopes from sediment input to arc output.

Sea level rise is one of the most disruptive consequences of global warming, threatening coastal populations and infrastructure worldwide. If we are to develop strategies to either adapt to, or mitigate against, that threat, we need to know what to expect in the future. The biggest uncertainty in estimates of future sea level is the contribution of the vast Antarctic Ice Sheet. Observations of thinning in some parts of the ice sheet have led to suggestions that an irreversible change may already be underway that could add over a metre to sea level over the coming centuries. Thinning is most prominent in the Amundsen Sea sector of the ice sheet, where it has been observed to spread inland from the coast, and to affect neighbouring outflow glaciers in a similar way. Those facts demonstrate that some change in ocean-driven melting of the glacier termini has been the trigger of change, leading to a widespread belief that warming of the ocean waters, driven ultimately by global warming, is responsible. However, observations of ocean temperature in the Amundsen Sea suggest a more complex history. The records start in 1994, and include only a few observations prior to 2009, but suggest cycles between warm and cool conditions occurring over decadal periods. That motivates a major rethink of how the ocean interacts with the ice sheet to produce the observed thinning. In this project we plan to exploit new techniques to fill the gaps in the record of ocean temperature change in the Amundsen Sea. We will modify a robotic submarine so that it can over-winter beneath the pack ice, periodically measuring the properties and strength of the currents carrying warm water towards the ice. Those measurements will be complemented by fixed instruments that record continuously at selected locations and seal-borne sensors that will record the depth of the warm water wherever and whenever the seals dive below the surface to feed. We will relate these detailed observations of what is happening below the sea surface to changes in the height of the sea surface that can be detected by satellites. That will enable us to exploit the satellite records collected over three decades to infer past changes in the sub-surface ocean. The results will allow us to confirm the timing and magnitude of recent warm and cool cycles and relate them directly to the records of ice sheet thinning. To extend our knowledge of Amundsen Sea temperatures beyond the satellite era we will use a numerical model of the ocean circulation in the region to identify the patterns of atmospheric forcing that were responsible for the changes in temperature that we have observed. We will then examine reconstructions of the past atmospheric circulation to generate a history of the key atmospheric changes. Finally, we will investigate how those changes in the regional atmospheric circulation relate to global scale atmospheric change, providing us with the longer-term perspective that is needed to address the questions of what past conditions initiated the current thinning and what the future might hold. Should we find that the most recent decade is typical, and that earlier decades have been characterised by similar cycles in ocean forcing, we will have shown that predicting the future of the ice sheet requires an understanding of its response to extremes. Much like the coastal engineer planning for the impacts of climate change, who must construct sea defences to protect against the extreme levels generated when storm surges coincide with high tides, we need to understand how long and severe the warm extremes in the Amundsen need to be in order to trigger episodes of ice sheet thinning. We also need to know what combination of larger-scale modes of atmospheric variability produces the "perfect storm" in the Amundsen that can push the ice sheet out of balance. Our project will deliver the knowledge needed to address those critical questions.

Advanced nanotools including atomic force microscopy, optical microscopy and correlative microscopy are enabling techniques for discoveries and knowledge generation in nanoscale science and technology. Many R&D efforts have been directed towards the performance improvement of such kinds of techniques for soft matter. However, the greatest challenge faced by these leading edge techniques is the realization of high spatiotemporal resolution, non-invasive, multi-scale and multi-dimensional imaging and manipulation. We therefore propose NanoRAM, a 10 ESR Marie Sklodowska Curie Action Doctoral Network by close collaboration between academic and industrial partners around the theme of innovative nanotools and their industrial applications. NanoRAM will train a new generation of ESRs in the development and application of newly developed manipulation and characterisation nanotools in soft matter research. ESRs will be cross-pollinated with concepts and skills in instrumentation and soft matter characterisation, in particular in fast nanomechanical spectroscopy, nano-robotics, correlative super-resolution nanoscopy, nano biomechanics and mechanotransduction. These skills are applied to reveal for the first time the fast, high resolution, multi-level and 3D information for single cell biomechanics and nanomedicine. Excellent training in new scientific and complementary skills, combined with international and intersectoral work experience, will instil an innovative, creative and entrepreneurial mind-set in ESRs, maximising economic benefits based on scientific discoveries. These specialised, highly trained ESRs will have greatly enhanced career prospects and qualifications for access to responsibility job positions in the private and public sectors. The ultimate goal of NanoRAM is to consolidate Europe as the world leader in innovative nanotool techniques and their emerging applications in soft matter fields such as biomechanics, mechanobiology, and nanomedicines.

Fullerenes are football-shaped cages of carbon atoms, for the discovery of which the British scientist Harry Kroto won the Nobel prize in 1996. Inside the cage is an empty space. Chemists and physicists have found many ingenious ways of trapping atoms or molecules inside the tiny fullerene cages. These encapsulated compounds are called endofullerenes. One of the most remarkable methods was pioneered by the Japanese scientists Komatsu and Murata, who are project partners in the current proposal. They performed molecular surgery . First, a series of chemical reactions was used to open a hole in the fullerene cages. A small molecule such as dihydrogen (H2) was then inserted into each fullerene cage by using high temperature and pressure. Finally, a further series of chemical reactions was used to sew the holes back up again. The result was the remarkable chemical compound called dihydrogen endofullerene. A new notation even had to be invented to write the formula down. The result of encapsulating H2 in a C60 fullerene molecule is denoted H2@C60. In this project we will perform magnetic resonance experiments on derivatives of H2@C60. Magnetic resonance is a method in which a sample is placed in a strong magnetic field and illuminated with radiowaves. The nuclei of the hydrogen atoms produce a radiowave response that may be analyzed to obtain detailed information about the molecules in the sample, where they are located, and how they are moving. The most familiar form of magnetic resonance is magnetic resonance imaging (MRI) which is used in hospitals to obtain anatomical pictures and diagnose medical conditions.In this project we will perform magnetic resonance on H2@C60 compounds and their highly-symmetric substituted derivatives, which have a number of useful properties such as water solubility. We will study the motion of the H2 molecules inside the nanoscale cages.In one of the subprojects we will synthesize and crystallize H2@C60 molecules in such a way that they are held in a highly symmetrical crystal. According to certain theories, the hydrogen molecules will behave in an unusual way under these conditions. The molecules themselves will emit magnetic resonance signals, not just the nuclei. We will try to observe this phenomenon for the first time on solid materials.The second subproject concerns a phenomenon called ortho/para conversion. Werner Heisenberg received the Nobel Prize in 1932 for predicting that ordinary hydrogen has two distinct forms, called ortho and parahydrogen. This was proved to be correct. The H2@C60 forms therefore come in two different types, some containing ortho hydrogen, and some containing parahydrogen. We will study in situ how these two forms interconvert with each other, and in particular, whether the ortho/para conversion may be induced by light.If the effects are observed as expected, some important consequences may follow. In particular, it should become possible to enhance the strength of certain NMR signals by a large factor (up to of almost 1 million) by irradiating the sample with a suitable laser beam. If this works it will have implications for a wide range of sciences, possibly including medical MRI. One of the aims of this project is to perform the preliminary work which will determine the feasibility of this novel NMR enhancement scheme.

The COVID-19 pandemic is having substantial consequences on UK and global food and nutrition security (FNS). This project will undertake world-leading research to provide government, business and decision makers with the evidence that they need to develop a robust FNS response to the current pandemic. The pandemic is causing major shocks to the four pillars of FNS: access; availability; utilisation and stability. Examples include reductions in productivity (labour limitations), breakdown of norms of food systems (distribution, changed demand) and supply chain restrictions (e.g. shortages of agri-chemicals for crop management). Economic impacts are altering both supply, distribution and demand. Collectively these shocks are substantially altering food systems whilst in the longer-term normal processes of trade may not adapt appropriately leading to changes in the balance of traded commodities, reduction in food reserves and price increases. The issue of FNS is relevant to all members of society, particularly for those most vulnerable to shortages or price increases. The food sector is also a major part of the UK economy, as it contributes approximately £111 billion a year and accounts for over 13% of national employment. It is the UK's largest manufacturing sector. The project focusses on UK FNS which is heavily dependent on global markets. Nearly half of the food we consume is imported and UK livestock industries rely heavily on imported feed. Some countries have already restricted exports in order to supply home markets. Normal market forces, transportation and distribution networks may no longer be appropriate to provide national requirements. A priority is to understand how to increase capacity for self-reliance to maintain civic stability, a healthy population and to understand the ramifications for third countries. The aim of this study is to conduct an initial rapid FNS risk assessment and explore options for changes in agricultural production, trade and distribution to protect FNS without jeopardising wider ecological and climate goals. The Research Programme will deliver seven key outputs: 1. Report on rapid risk assessment of the global food system considering how direct and indirect COVID-19 impacts and responses are propagating risks to food and nutrition security. 2. Report on Rapid risk assessment of UK food system responses and vulnerabilities and consequences on access, availability, utilisation and stability. 3. A set of plausible scenarios to explore the cascading risks and consequences of pandemic impacts on food sand nutrition security. 4. Report on alternative land use and management options that will increase resilience. 5. Report and maps of the spatial assessment of the alternative land use and management options. 6. Report including infographics reviewing lessons learned from the pandemic to improve Food and Nutrition Security. 7. Two workshops and other dissemination events and report with recommendations. The knowledge and foresight generated will be applicable to and of value across multiple sectors of the economy. It will inform policy support and development within UK and devolved Governments and help industry and business make informed decisions and plan adaptations. Information generated will support the UK's strong position in global trade. Identifying data gaps now will enable improved monitoring of impacts, both at UK and global scales.