Recent events have demonstrated the need for readiness for medical supply and equipment rapid manufacturing repurposing. Eur3ka will deliver a trusted and unique capability to plug and collectively respond to a sudden demand increased in a coordinated and effective manner at unprecedented scale. Eur3ka mission is to bring together most recent R&I results in (1) Industry 4.0 standards, open automation modular manufacturing production line enablers; (2) industrial international common data space enablers and digital infrastructures; (3) global on-demand and manufacturing as a service platforms; (4) connected and smarter supply networks, and global medical supplies and equipment repositories; (5) the vibrant European and Global network of manufacturing DIH network innovation services and open experimental facilities. The main ambition of Eur3ka is to enable and facilitate global and fair access to (1) a Plug & Respond (P&R) repurposing resource coordination framework for pandemic crisis response, (2) a common open standardized modular manufacturing reference architecture and solutions, and (3) top digitally sovereign cross-sectorial manufacturing networks and capacities that should allow to connect global manufacturing and supply chain capabilities and medical knowledge on-demand and as-a-Service across the globe in an IP-responsive manner to ensure rapid manufacturing repurposing for an increased and sudden demand of medical supplies and equipment. Eur3ka builds and extends the existing Global Network of Advanced Manufacturing Hubs (AMHUBs) to leverage a comprehensive COVID response based on solid socio-tecno-economic pillars that bring together advanced manufacturing and digital enablers that will raise robustness, redundancy, resourcefulness, response, and recovery against current and future pandemics. Eur3ka vision builds on and accelerate current digital transformation industry 4.0 efforts, as well as flexible regulations and tailored workforce re-/up- skilling

The Flex4fact project aims to develop an end-to-end ecosystem that takes a modular approach to enable flexible manufacturing in industry and create the conditions for the necessary energy transition in which all stakeholders can participate and benefit. Currently, complex process industries and the segment of mixed clusters and distributed renewable energy flows are not covered. Indeed, at least three key elements of the Flex4Fact approach differ from current offerings: 1) enabling industrial flexibility through digital process twinning and machine learning techniques to address complex operational scenarios and exploit the full potential of the selected industrial cases; 2) the end-to-end approach of the Flex4Fact platform, covering the entire technology stack required to achieve the results; 3) a modular and multi-level approach that leverages flexible, hybrid architectures, open protocols, and standard interfaces to enable greater flexibility in the system itself and associated service offerings, remove barriers to entry for vendors in the value chain, and ensure data communication with existing IT legacy systems. As a digital enabler for flexible energy consumption, the Flex4Fact platform will meet the needs of companies of all sizes, including SMEs that are affected by rising energy prices and have less "financial muscle" to deploy a combination of IT, manufacturing, and energy solutions (93% of European companies have fewer than 10 employees and only 1 in 5 SMEs are highly digitized). The Flex4fact platform will also reduce the digital divide between North and Southern Europe, another crucial aspect for European competitiveness: in fact, it will be developed by a balanced European consortium in which critical technologies will be developed and implemented by several partners in five industrial contexts, from North to South in Europe.