The vision of the NAMWISE project is to provide a supporting framework to pave a scientifically substantiated way towards a paradigm-shift in (eco)toxicology that will not rely on in vivo data. To fulfil its vision the project will leverage the acquired knowledge on New Approach Methodologies (NAMs) and then gather new input from all stakeholders to refine, improve and optimize their use in regulatory contexts for chemicals and pharmaceuticals. The project will merge under its umbrella inputs from a multi-disciplinary consortium comprising academia, NAM-developers, NAM users (CROs), regulators while reaching out towards societal expectations. The workplan of NAMWISE is organized along far-reaching objectives driven by the interest for all the stakeholders: 1. Sustain and amplify the momentum built by similar initiatives by combining expertise on in silico tools, in vitro assays and a widespread network with external projects. 2. Provide a pragmatic approach based on case-studies for hazard/risk assessment and drug efficacy that will guide the project in implementing NAMs strategies. These procedures will be submitted to a peer-review to ensure that what the NAM community receive is of a high standard. 3. Deliver an analysis of requirements in terms of standardization and validation of NAMs that benefits from the input of the PEPPER platform on pre-validation, a unique French initiative on NAMs based on public and private funding. 4. Foster fruitful interactions between stakeholders catalyzed by several actions, including a series of workshops and training initiatives targeted on the needs of CROs identified during the project. 5. Propose a way forward for solving NAMs’ shortcomings and enhancing their drivers. Finally, the project will provide a white paper during its final open symposium that will render NAMWISE a major reference point and essential force for bringing forward proposals for animal-free chemical and drug assessments.

The overarching goal of CCUS ZEN is the accelerated deployment of CCUS throughout Europe, which will be achieved by: • Sharing knowledge and disseminating information important for stakeholders to make informed decisions on CCUS • Developing specific and actionable plans for the development of CCUS value chains As CCUS developments around the North Sea (NS) region are relatively mature, CCUS ZEN will leverage these developments as best practice for the development of new CCUS value chains in the currently underdeveloped Baltic Sea (BS) and the Mediterranean Sea (MS) Regions. While CCUS value chains, i.e., the entire pathway from CO2 capture to transport to its eventual storage or utilization, can today be realized, the industry is still in its infancy and many issues must be addressed to achieve the rapid deployment required. The consortium, consisting of 15 partners, including 2 associations with over 400 members in total, brings together entities with leading expertise on all aspects of CCUS value chains. 30 organisations, representing industry, RTOs, Associations, clusters, ports and municipalities involved in the development and deployment of CCUS value chains, will contribute their expertise as networking partners. Starting from an analysis of the technical and non-technical state-of-play in the BS and MS regions, CCUS ZEN will select at least eight value chains (four in each region) for detailed study and comparison with successful value chains from the NS region. One value chain from each analysed region will then be selected as most promising, with a detailed plan for further development. Through its knowledge-sharing activities and transfer of best practices from the NS region, CCUS ZEN will provide an information basis for the future CCUS value chains, including policy recommendations and a blueprint for CCUS value chain development, including easily accessible technology and CO2 source mapping, generic technical frameworks and business plan models.

PET is widely used in plastics and textiles leading to over 20 Mt/y of complex waste worldwide for which no closed-loop recycling is viable today. Most complex waste is landfilled or incinerated. There is an urgent need to develop a circular solution to convert complex PET wastes from plastics and textiles back into high-added value products. WHITECYCLE unites 3 brand-owners, 1 PET converter, 2 waste managers, 1 digital deeptech for smart sorting, the world leading enzymatic recycling SME, 1 LCA company, 3 UNIs/RTOs, 1 cluster and 1 management firm. They aim to demonstrate two new processes combining strong scientific and industrial know-how: (i) innovative identification, sorting and separation technologies that will dramatically increase the PET content of complex waste streams to 80%, and (ii) a disruptive enzymatic recycling process that is expected to yield pure PET monomers sustainably even for impure waste streams. PET monomers obtained will be repolymerised and recycled. Thus, 2 t of waste will be used to demonstrate 3 highly technical PET-containing pilot series: 100 tyres, 1,500 m of lay-flat hoses and 400m2 of multicomponent fabric that will be coated and used to manufacture 4 lines of technical garments. Process design kits, LCA and production cost estimates will be provided to PET manufacturers and waste management companies for rapid deployment and assure social acceptance. First projections show that WHITECYCLE’s recycled PET will be competitive with virgin PET. The project will conduct a full circle loop from real complex waste feedstock to representative product of the 3 use-cases at TRL 5. Then, a strong upscale study will allow the process steps to reach TRL 6 to 8. By 2030, WHITECYCLE will enable the annual recycling of more than 2 Mt of PET, which corresponds to the amount of additional recycled PET needed to meet the EU’s 2030 targets. This will reduce emissions by around 2.06 Mt CO2eq and avoid the landfilling of more than 1.8 Mt of PET.

IMAGHyNE will pave the way for the deployment of a large-scale renewable hydrogen (H2) economy in the Auvergne-Rhône-Alpes region, fully integrated in the energy system and addressing the needs of high emitting sectors. The objectives will be to: 1) deploy 62 MW of new electrolysis capacity, 2) implement a flexible H2 supply chain combining underground storage and tube-trailer deliveries 3) deploy 13 multi-modal H2 refuelling stations, 4) deploy 200 on-road fuel cell vehicles, 5) deploy 58 off-road fuel cell vehicles and stationary equipment, 6) strengthen the robustness of the energy and H2 supply chain by integrating a flexible industrial player, 7) design an efficient pipeline-based multi-user H2 ecosystem, 8) prepare for additional large-scale deployment as part of the Valley extension (including IPCEI) and its replication, 9) disseminate and communicate the results of the project to a wide audience. IMAGHyNE will meet the requirements of the Work Programme and contribute to the EU’s H2 strategy. IMAGHyNE will foster the development of a long-lasting H2 economy through: 1) an extension of the Valley including the development of a pipeline network and the transition of several industries part of the observer group, 2) an ambitious replication strategy with at least 5 territories from European countries (France, Italy, Spain, Portugal, Switzerland), and airports, 3) high quality communication and dissemination activities including training, 4) recommendations to public authorities on regulation (e.g. tunnels). This ambition will be achieved thanks to the involvement of key public and private entities covering the entire H2 value chain, with an extensive experience of EU-funded projects, who have defined a detailed governance structure, Work Plan and financing strategy. IMAGHyNE partners will work collectively to create links and synergies with upcoming and existing Valleys already supported by the Clean Hydrogen Partnership.