Our international and transdisciplinary project that will be proposed for Horizon EU funding focuses on personalized primary prevention in health. Our goal is to develop a global approach to primary prevention of chronic diseases that integrates the diversity of contexts, such as chemical, nutritional, cultural and socioeconomic environments. To do so we aim to target the molecular profiles associated with early epigenetic aging mediated by oxidative stress and to propose interventions based on diet that influence the epigenome. Our ultimate objective is to revert the progression towards abnormal epigenetic aging by promoting a protective diet in preadolescents who belong to communities at highest risk. The state-of-the-art in primary prevention is to link the risks of noncommunicable diseases (NCDs) identified epidemiologically to molecular mechanisms, in order to intervene in a personalized manner. The development of most NCDs, and particularly cancer, is linked to epigenetic changes that may be targeted for reversion to ‘normal’ as long as the epigenetic molecular mechanisms associated with risk development are known. The development of chronic disorders has been associated with abnormal epigenetic aging of tissues, and aging is linked to oxidative stress that can be initiated by environmental exposure such as pollutants and inappropriate diets. Moreover, inequalities related to socioeconomic contexts are recognized as an integral part in the establishment of the risk of NCDs, and low socioeconomic status and its consequences on lifestyle and chronic stress are associated with epigenetic changes. Our innovative concept places the notion of risk for NCDs in a multifactorial framework, from core epigenetic molecular mechanisms leading to NCD development to health determinants. Such concept requires integrating the exposome and its metabolomic impact in order to obtain the stratification necessary to identify communities at highest risk thanks to biomarkers from epigenetic origin. The systematic identification and use of available data resources on the different aspects of life sciences and social sciences that are associated with cancer risk described above are essential for the project. Our proposal justifies the choice for a Horizon EU funding call that focuses on global aspects of health determinants with the support of data science, to propose new methods for prevention. The preparation of the Horizon proposal requires that we extend our already existing International Breast Cancer & Nutrition (IBCN) network to reinforce the participation of EU countries and to integrate new disciplines to our transdisciplinary efforts, notably via experts in artificial intelligence and in data sciences from multiple sources. The preparation phase of the Horizon proposal outlined for the MRSEI includes the recruitment of additional expertise, the identification of the resources for multiple types of data, the identification of the conditions to apply the proposed research tools and intervention, further assessment of nutriepigenomic information, and the organization of regular working group meetings as well as a scientific think-tank.