SYSCHEMIQ will demonstrate how to migrate to a circular urban-industrial cross-border district, i.e. the CHEMELOT Circular Hub (CCH) in the Trilateral Euregio of NL, BE and DE. A Circular Economy Action Plan and a (4BEUR) Investment Agenda (2020-2030) are available. Stakeholder involvement schemes are in place, to allow governance within an ecosystem (Regional Government, Municipality, Industries, Educational and Research Institutes, Utilities and Cluster Management): a new way of working to overcome key-bottlenecks. Investment decisions have been made to set up mechanical recycling (4kT/a) and a 150 M€ semi-industrial (18kT/a) chemical pilot recycling plant, to run demos with optimised real-life Mixed Plastic Waste (MPW) streams. We will demo systemic solutions 1) a novel Dual-Track multistakeholder governance model, underpinned by the recently developed Plastic Recycling Impact Scenario: PRISM model (TRL6), and CIMS digital-twin 2) the CCH circular governance model (TRL6), 3) community-based innovation schemes; a Circular City Lab, citizens incentives schemes, incubator and novel skills development and innovation programmes with students (vocational, professional and academic) in a Circular Learning Lab (CHILL), 4) new plastic waste collection, sorting standards/protocols and technologies (e.g. prototype sorting line TRL6) for alignment of material flows in the value chain, 5) new Design rules (TRL 5) for plastic packaging products favouring mechanical and chemical recycling. Considering circa 1.1 Mt of MPW in NL and 30 Mt in EU, scenario calculations promise huge savings of 11.4 Mt CO2 eq./a and 190 kT/a virgin polyolefins. Business modelling and upscaling study will prepare investments in a 100-400 kT/a full-scale recycling facility. A structured Twinning programme with at least 5 selected regions (incl. Flanders and Lombardy), will foster replication, with the support of EU Platform organisations (ECRN, PRE) and in collaboration with the CCRI.