This project aims, in a context of organ avilabily shortage and the desire to control expend on public health, increase the number of endpoints on a graft to optimize the processing conditions, and give the possibility to delegate the explantation of organs to a team without mobilize and move precociously the team receiving center. Given the importance of the shortage of grafts, the Agency for Biomedicine (ABM) promotes the expansion of indications for organ transplant Non-Heart Beating Donors (NHBD), which also broadens the risk to the quality of the organ and its preservation. During his transplant, an organ is submit to conditions different of its normal physiological context (ischemia, cooling, ...), which induces stress and trauma that may affect the restoration of its function after transplantation. Continuous monitoring of organ physiological status associated to its temperature, would allow a better understing of the evolution of the conservation status of the organ. Learning about graft and its behavior during the transplantation period (strating from the explantation phase, until the reperfusion phase after tranplantation / preservation) will allow a better understing of the function retrieval and therefore better sizing treatment post-transplant (dialysis, medication, ...). In addition, as part of cardiac and liver transplantation among other things, we are at a time when every team is searching the pooling of harvest. The harvest delegation would be possible by the development of a device providing complete traceability as well as monitoring the quality of the organ which would save the samplers fatigue of travel and allow the public health system to reduce expenses on logistics costs. The aim of this project is the development of such a device.

Curing neurodegenerative diseases such as dementia is a major unmet biomedical objective costing handicap, life expectancy, and approximately €130 billion per year. This positions age-related neurodegenerative diseases as the leading medical and societal challenges faced by EU society. Accessing the brain to decipher pathological targets for therapy is the main bottleneck for molecular and personalized therapy breakthrough as observed now in oncology. Deep brain stimulation (DBS) remains the only non-lesional approach to explore different brain nucleuses in different diseases, thus, offering a unique temporary access to the pathological tissue in vivo, in awaken patients and at earlier stage of disease. Here our project proposes to take advantage of DBS surgery to harvest a molecular imprint from implanted patients. Taking advantage of the unique advantages of nanotechnologies we invented and patented a dedicated device based on nanoporous surfaces directly implemented on the surgical tools for optimal brain tissue harvesting. Our project has the following objectives: (i) complete the preclinical regulatory documentation of the technology, (ii) finalize the industrial GMP process for nanoporous fabrication as well as the final device association (iii) perform a proof-of-concept trial in neurostimulated patients addressing clinical operapility, safety and compatibility with poly-omics investigations. Ethical as well as societal perception will be anticipated. Complete integrated data mining will ensure the quality management of the project, mandatory for CE norm validation. This project will provide the first validation of a new medical procedure “molecular and cellular nanoporous fingerprint” paving the way for targeted therapy in neurodegenerative disease. Israeli, Swedish and French academic groups will work synergistically to ensure a rigorous EU dissemination of nanomedical innovation, also using this project to progress in the field of ethics, societal perception and “nanomedtech” regulation in Europe. The well-established academic/industry partnership of the project will allow accelerating the preclinical and clinical validation of the device, thereby guaranteeing an efficient industrial transfer and medical dissemination for EU patients with neurodegenerative disease.