Natural Rubber (NR), a biopolymer produced from the latex of Hevea brasiliensis, exhibits very specific properties never mimicked by synthetic rubbers. NR is thus a highly strategic material for the production of tires or others items. However, NR presents important drawbacks: i) the rather non consistency or variability of its properties, ii) a structuration dynamics or “storage hardening” that is still not fully understood. The RUBBex project aims to study and identify the main biochemical components (poly(cis-1,4-isoprene), proteins and lipids) and the mechanisms involved in the structuration of NR in order to optimize the performances of raw NR. The main objective of the RUBBex project is to generate new knowledge that will allow targeting new treatments before processing for a better control of the variability of NR properties and of the NR structuration dynamics with time. A multidisciplinary and biomimetic approach will allow the study of this material from fresh rubber particles (organization, composition) to the raw NR (composition, structures, properties). The achievement of this multidisciplinary project relies on the complementarity of 6 partners (3 French academic laboratories, Michelin Company and 2 Thai academic laboratories). They will share their expertise in analytical chemistry, macromolecular chemistry, structural characterization, properties of materials, biochemistry, biophysics and spectroscopies.