Organen op Chip vormen een nieuwe veelbelovende klasse van micro-gefabriceerde devices voor in vitro studies van biologische systemen. Transwell systemen zijn de hedendaagse standaard voor in vitro studies. De Boxense in combinatie met de IET-plate maakt kwaliteitsmonitoring van deze systemen mogelijk. Dit is essentieel voor toepassing van in vitro studies binnen de farmaceutische industrie.

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Positron Emission Tomography (PET) is a medical imaging method to measure (patho)physiological processes in patients non-invasively. Clinical applications include cancer, neurology, cardiology, and inflammation/infection monitoring. PET relies on short-lived radiopharmaceuticals labelled with 18F. Current production methods are inefficient, leading to incomplete reactions and wasted materials. Our research focuses on developing a fully integrated microfluidic chip for efficient PET-radiopharmaceutical production. This chip can produce PET tracers faster, with higher yields, lower reagent consumption, and faster purification. The goal is a fully automated procedure suitable for commercialization, enabling faster and more accurate diagnoses and treatments for patients worldwide.

Organs-on-chips are cultured mini-organs that are used to study the safety and efficacy of food and medical drugs. The development of new organs-on-chips is complex, because it relies on expertise in microfabrication, microfluidics, cell culture, tissue engineering and microscopy. The new facility ‘hDMT INFRA OoCDev’ will enable the development of innovative organs-on-chips by bringing together groundbreaking infrastructure and technical expertise. The facility will be embedded in a national organization and will play an important role in boosting the development of even more realistic organs-on-chips.