The WELL CARE project aims to strengthen supports available to long-term care (LTC) workers and informal carers for improving their resilience and mental well-being through care partnerships. The WELL CARE project has four specific objectives for these target groups: 1) To review, organise and make available evidence and data (with a focus on gender, inclusion, occupation and non-occupation specific factors) on how to best support resilience and mental well-being: we will identify and analyse 40 good practices and perform 10 in-depth case studies; 2) To identify, evaluate and promote the adoption of innovative solutions and prototypes: we will develop 5-8 general solution prototypes, which will be implemented and tested with interested stakeholders (e.g., LTC providers and employers) in five European Union countries (Germany, Italy, Netherlands, Slovenia, Sweden). We will provide resources, guidance and a helpdesk to sustain implementation and the creation of favourable local, regional and national ecosystems; 3) To develop and foster evidence-based and action-oriented recommendations for policy makers and stakeholders: we will analyse the policy, legislative, service and financing frameworks, also elaborating recommendations on the basis of data and evidence generated by the project; 4) To develop, implement and sustain a continuous process of research and co-design activities with end-users and stakeholders at national level: we will set up and implement Blended Learning Networks, establishing a participatory research design and addressing real needs and perspectives from the target groups. The WELL CARE project will positively impact LTC workers’ and informal carers’ mental health and productivity (micro-level), as well as providing LTC providers with new solutions and tools for effective, efficient and sustainable support and retainment of the care workforce (meso-level) and new data and recommendations for policy makers and stakeholders (macro-level).