To strengthen EU's ability to fight DENV and WNV epidemic and pandemic threats and elaborate effective emergency plans. The project is based on three pillars: 1) clinical investigation of host factors related to severe disease, 2) therapeutic development (i.e. host-viral protein binding inhibitors) and 3) One-Health-based surveillance of the infections. Open science practices will guarantee quality, efficiency of the research and maximise the impact of the project. The declaration of interest in the InFlaMe project of a company, world leader in the field, supports the thrustable of the network and the impact of the project’s expected outcomes. The project’s tasks will proactively be addressed in 7 sounding work packages and will go beyond the state-of-the-art. The partners have outstanding experience in all the aspects of the project, collaborated previously and working together on emerging flaviviral infections. The team includes Fondazione IRCCS Policlinico San Matteo as coordinator (IT; Fausto Baldanti), the National Institute of Molecular Genetics (IT; Renata Grifantini, Antonio Lanzavecchia and Raffaele De Francesco), Pasteur Institute (FR; Jouvenet Nolween), CIC Biogune Institute (ES; Jesus Jimenos-Barberez and Nicola Abrescia), University of Florence (IT; Cristina Nativi), Centro Nazionale per le Ricerche (IT; Giovanni Maga and Paolo Mazzetti ), Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IT; Ana Maria Moreno Martin), IMAGINE Institute (FR; Jean Laurent Casanova and Shen-Ying Zhang,), University of Vienna (AT; Judith Aberle and Karin Stiasny) and University of Masaryk (Daniel Ruzek). This truly complementary and collaborating network has a robust know-how in diagnosis of flaviviruses in humans and animals, on host-pathogen interaction and drug discovery.

The European Partnership Animal Health & Welfare (EUP AH&W) will provide society with a sustainable production for both terrestrial and aquatic animals, where infectious animal diseases are prevented and controlled, antimicrobials are used prudently, and a high level of animal welfare is provided in every phase of animal’s life. The objectives of the EUP AH&W fit in with the European Green Deal and its associated Farm to Fork strategy for a fair, healthy, and environmentally friendly food system. From its start, the EUP AH&W includes 56 Research Performing Organizations (RPO) and 30 Funding Organizations (FO) from 24 EU and non-EU European countries. The RPO partners provide significant research-based advice to competent authorities in the EU and are the backbone of Animal Health & Welfare (AHW) research in Europe. They collaborated to transpose 16 actions from the EUP Strategic Research and Innovation Agenda (EUP SRIA) into 17 joint internal projects. The FO partners will contribute through external calls to further R&I actions from the EUP SRIA not covered by internal activities as they require other expertise or industry participations. Due to the close link between animal health and welfare and human well-being, the One Health-One Welfare perspective will take a prominent place in the EUP AH&W. The mobilisation of resources from both RPO and FO together with EC co-funding will allow the Partnership to achieve ambitious goals for AHW at the transnational level, in Europe and beyond. New technologies develop rapidly and provide new R&I opportunities for AHW, to be included in the EUP AH&W as joint internal activities and projects initiated through external calls. The management will set up appropriate procedures and methodologies to ensure a fair coverage of AHW, of terrestrial and aquatic animal species, the various priority areas and to ensure the uptake of the results in the midterm (outcomes) and long term (impact) for science, society and policy.