Developing new health technologies is complicated and often fails to lead to improved patient care. Successfully taking an idea through the necessary research studies and developing it to the point of use in the NHS requires many different areas of expertise. These include; understanding patients' and health professionals' needs, medical and healthcare environments, engineering and digital technologies, design, manufacturing, legal and ethical regulation, business development, how to obtain funding, and many other topics (in our application we refer to these areas the "Innovation Curriculum"). Our Hub covers a region of 1.4 million people in a region that is affected by high levels of disease and health inequalities. Our team includes all regional NHS organisations including GPs, adult and children's hospitals, mental health services and the recently introduced South Yorkshire "Integrated Care System", hundreds of researchers from the University of Sheffield and Sheffield Hallam University, many large and small companies, and patient and public groups. These partners between them have all the necessary expertise and experience in developing new Digital Health technologies to the point of use in the NHS. We will help researchers develop Digital Health technologies by training them in all aspects of the Innovation Curriculum, and by supporting them to work together with the NHS and patients on real ideas and projects. We will hold Citizen's Juries to understand the public and patients' views of Digital Health and to help design our research. We will produce sixty hours of training in Digital Health for researchers, clinicians, patients and the public, freely available and accredited through our partnership with YouTube's authoritative health content programme. We will hold regular "Calls for Ideas" where we support project teams and train them in Digital Health, providing the most promising ideas with initial project funding to help take these towards potential commercialisation.

DRIVE-Health will train a minimum of 85 PhD health data scientists and engineers with the skills to deliver data-driven, personalised, sustainable healthcare for 2027 and beyond. Co-created with the NHS Trusts, healthcare providers, patients, healthtech, pharma, charities and health data stakeholders in the UK and internationally, it will build on the successes of its King's College London seed-funded and industry-leveraged pilot. Led by an established team, further growing the network of funding partners and collaborators built over the past four years, it will leverage an additional £1.45 of investment from King's and partners for every £1 invested by EPSRC. A CDT in data driven health is needed to deliver the EPSRC Priority for Transforming Health and Healthcare, EPSRC Health Technologies Strategy, and on challenges laid out in the UK Government's 2022 Plan for Digital Health and Social Care envisaging lifelong, joined-up health and care records, digitally-supported diagnoses and therapies, increasing access to NHS services through digital channels, and scaling up digital health self-help. This ambition is made possible by the increasing availability of real-world routine healthcare data (e.g. electronic health care record, prescriptions, scans) and non-healthcare sources (e.g. environmental, retail, insurance, consumer wearable devices) and the extraordinary advances in computational power and methods required to process it, which includes significant innovations in health informatics, data capture and curation, knowledge representation, machine learning and analytics. However, for these technological and data advances to deliver their full potential, we need to think imaginatively about how to re-engineer the processes, systems, and organisations that currently underpin the delivery of healthcare. We need to address challenges including transformation of the quality, speed and scale of multidisciplinary collaborations, and trusted systems that will facilitate adoption by people. This will require a new generation of scientists and engineers who combine technical knowledge with an understanding of how to design effective solutions and how to work with patients and professionals to deliver transformational change. DRIVE-Health's unique cohort-based doctoral research and training ecosystem, embedded across partner organisations, will equip students with specialist skills in five scientific themes co-produced with our partners and current students: (T1) Sustainable Healthcare Data Systems Engineering investigates methods and frameworks for developing scalable, integrated and secure data-driven software systems (T2) Multimodal Patient Data Streams will enable the vision of a highly heterogeneous data environment where device data from wearables, patient-generated content and structured/unstructured information from electronic health records can combine seamlessly (T3) Complex Simulations and Digital Twins focuses on the paradigm of building simulated environments, including healthcare settings or virtual patients, to make step-change advances in individual predictive models and to inform clinical and organisational decision-making. (T4) Trusted Next-Generation Clinical User Interfaces will place usability front and centre to ensure health data science applications are usable in clinical settings and are aligned with users' workflows (T5) Co-designing Impactful Healthcare Solutions, is a cross-cutting theme that ensures co-production and co-design in the context of health data science, engagement with stakeholders, evaluation techniques and achieving maximum impact. The theme training will be complemented with a cohort and programme-wide approach to personal, career, professional and leadership development. Students will be trained by an expert pool of 60+ supervisors from KCL and across partners, delivering outstanding supervision, student mentoring, opportunities, research quality and impact.