In contexts of crimes, disasters, terrorism or population displacement that presently occurs in Europe and numerous regions of the world, the necessity of having as soon as possible reliable, high throughput and real time analysis to identify individuals, victims and authors is a major societal and legal issue. The present MRSEI ForOnBoardLab project aspire to strengthen a multidisciplinary consortium which was federated, during a PhD thesis, around the theme of the rapid DNA analysis in the aim to structure a project for answering to the European H2020 call "SU-FCT02-2018-2019-2020: Technologies to enhance the fight against crime and terrorism, Sub-topic 1: [2019]; Trace qualification" at the beginning of 2019. The ambition of our European project is to set up a technological and normative European st of references, procedures and guidelines in the field of the genetic identification using high throughput DNA fingerprints, in real time and on site. In this way the project also aims at developing innovative biological collection devices and smart and on-board mobile laboratory in agreement with standards and reglementations and qualify and validated instruments and analytical methods. This in situ and real time forensic approach involves 9 academic, institutional and industrial partners from 6 European countries: France, Switzerland, Greece, Italy, Luxembourg, Belgium with intrernationaly recognized forensic leaders in DNA analysis performing more than 150 000 expertises by year. ForOnBoardLab aims to initiate and catalyse during 18 months the consortium to propose a structuring program in the H2020. Such a support of the French ANR within the framework of the AAP MRSEI will enhance the emergence of an European network in the field of biological sampling integrated into solutions of analysis high throughput , in situ and real time DNA including trainings and normative functions in a guides of recommanded practices to collect traces in complex crimes/disasters or major population migrations fields

Dental implants are artificial tooth roots made of specific material with a part of the structure that cross the gingival mucosa and support a crown. Each year millions of implants are placed and a quarter of the adult population will be concerned in 2026. Bacterial infection occurs if the soft-tissue barrier that protect the alveolar bone from the outer environment is not strongly sealed to the implant and led to severe medical issue called peri-implantitis. That clinical problem, found in 20% of the cases, compromise the therapeutical solution and the economic costs associated is dramatic. It is crucial to resolve long-term dental implant biointegration. A versatile bioactive bifunctional medical grade coating - that will favor the integration with the surrounding tissue while preventing bacterial infections- with the potential to serve both in prevention than in treatment will be designed and developed at the implant surface. The evaluation of the bioactivity and the potential synergy of a low elastic modulus titanium alloy vs standard one will be evaluated. The opportunity to prevent peri-implantitis with the covering of the implant before implantation will be validated. The possibility to reapply in situ (in a clinical setting) the coating for the treatment of a peri-implantitis will be developed. This project is highly innovative in the field of oral implantology as we propose smart and versatile solutions to treat dental implant with the opportunities offered by low elastic modulus material to improve the stability of the bone-implant interface and the tuning of the deposition system of the bioactive coating layer, especially with the optimization of the spraying strategy, for easy clinical use and potential new method of re-treatment. This project synergizes the efforts of researchers, clinicians, and present a real potential of transfer with the implication of two companies commercially active in implant coatings and dental implant production respectively.

In our daily lives, all conventional man-made adhesives are petrochemical products, which are toxic for the body and show limited efficiency in wet conditions, major drawbacks for biomaterials. In this project, we aim at producing adhesives effective in air and/or in wet conditions inspired by natural glues of some arthropods. For these animals, the adhesion mechanism seems to be related to protein self-assembly on the surface. The adhesive proteins show particular sequences with repetitive architectures that allow a genetic engineering strategy for the production of biomimetic adhesives. The structural properties and the self-assembly of engineered adhesive-like proteins will be characterized as well as their adhesion on different model materials. This approach using simplified mimics of biological adhesives will facilitate better understanding of systems from which they are derived and could find applications in medicine as well as in biotechnology and industry.

Societies face to contexts of insecurity. Reliable and timely information are a challenge in characterizing threats. So, among found traces, analysis of biological traces (DNA) is relevant. The majority of on-site taken samples are “blind-samples” taken from supports, which are the most likely to harbour biological traces left by contact of an individual’s body part (“touch DNA”). However, the poor efficiency in getting informative DNA profile from such samples (about 30%) is a major hurdle. As DNA analyses are very sensitive (from few cells), it could ensue from upstream unsatisfactory steps, for example insufficient biological material collection. BioTrack bases on a crosscutting approach between fundamental research, applied look and end-users validation. It aims at improving the pre-analytical steps of DNA analysis, i.e detection, collection and recovery of biological traces, aided by decision-support tools, to increase the chance of getting informative profiles form touch DNA.

The CellulARIUMs@CY project, Cergy PAris University (CYU) and the Parc Aux Étoiles aim to introduce citizens to the research conducted in their region, which extends over the western Parisian area, covering the Grand Paris Seine et Oise urban community, the Val d'Oise (one of the youngest departments in France), and the Vexin. By offering innovative mediation devices, giving voice to researchers, and leveraging digital tools to make research immersive and inclusive, CYU and PAE aim to promote creativity and the dissemination of scientific culture. As part of this call for proposals, CYU and PAE wish to build on their existing partnership to offer a comprehensive mediation service focused on different scales of life, particularly developing initiatives around Biology, which can complement existing ones in Astrophysics. The ERRMECe unit focuses on the interactions between cells and their environment, particularly their extracellular matrix. The work is carried out with a multi-scale approach, from the molecular and cellular level to organisms and ecosystems, and according to a multidisciplinary approach crossing perspectives from biophysics, molecular biology, cell biology, microbiology, animal and plant physiology. This research extends into areas of application related to health and well-being (aging, oncology, tissue engineering, regenerative medicine), as well as safety (forensics) and ecology (biodiversity preservation, agroecology). With the CellulARIUMs@CY project, the team aims to: - Increase the accessibility of the aforementioned Biology resources to enable an inclusive mediation approach. - Develop immersive approaches in Biology to support scientific mediation work and facilitate the dissemination of scientific results from ongoing programs. - Identify interfaces and analogies with the scientific mediation work carried out in the field of Astrophysics to propose initiatives across the entire scale spectrum of life (from the microscopic to the infinite scales).