Living beings share the same embodiment for sensing and action. For instance, the spindle sensors that provide the feeling of a joint angle and speed are embedded on the muscles that actuate this joint. The tendon sensors that provide the feeling of force too are directly involved in actuation of the joint. Do the function of these sensors change when the muscles are activated to take action? Does the co-activation of antagonistic muscles play a role not only in actuation, but also in perception? This project will investigate these questions through targeted experiments with human participants and controllable stiffness soft robots that provide greater access to internal variables. Recent experiments we have conducted on localising hard nodules in soft tissues using soft robotic probes have shown that tuning the stiffness of the probe can maximise information gain of perceiving the hard nodule. We have also noticed that human participants use distinct force-velocity modulation strategies in the same task of localising a hard nodule in a soft tissue using the index finger. This raises the question as to whether we can find quantitative criteria to control the internal impedance of a soft robotic probe to maximise the efficacy of manipulating a soft object to perceive its hidden properties like in physical examination of a patient's abdomen. In this project, we will thus use carefully designed probing tasks done by both human participants and a soft robotic probe with controllable stiffness to access various levels of measurable information such as muscle co-contraction, change of speed and force, to test several hypotheses about the role of internal impedance in perception and action. Finally, we will use a human-robot collaborative physical examination task to test the effectiveness of a new soft robotic probe with controllable stiffness together with its stiffness and behaviour control algorithms. We will design and fabricate the novel soft robotic probe so that we can control the stiffness of its soft tissue in which sensors will be embedded to obtain embodied haptic perception. We will also design and fabricate a novel soft abdomen phantom with controllable stiffness internal organs to conduct palpation experiments. The innovation process of the above two designs - the novel probe and the abdomen phantom - will be done in collaboration with three leading industrial partners in the respective areas. The new insights will make a paradigm shift in the way we design soft robots that can share the controllable stiffness embodiment for both perception and action in a number of applications like remote medical interventions, robotic proxies in shopping, disaster response, games, museums, security screening, and manufacturing.

Living beings share the same embodiment for sensing and action. For instance, the spindle sensors that provide the feeling of a joint angle and speed are embedded on the muscles that actuate this joint. The tendon sensors that provide the feeling of force too are directly involved in actuation of the joint. Do the function of these sensors change when the muscles are activated to take action? Does the co-activation of antagonistic muscles play a role not only in actuation, but also in perception? This project will investigate these questions through targeted experiments with human participants and controllable stiffness soft robots that provide greater access to internal variables. Recent experiments we have conducted on localising hard nodules in soft tissues using soft robotic probes have shown that tuning the stiffness of the probe can maximise information gain of perceiving the hard nodule. We have also noticed that human participants use distinct force-velocity modulation strategies in the same task of localising a hard nodule in a soft tissue using the index finger. This raises the question as to whether we can find quantitative criteria to control the internal impedance of a soft robotic probe to maximise the efficacy of manipulating a soft object to perceive its hidden properties like in physical examination of a patient's abdomen. In this project, we will thus use carefully designed probing tasks done by both human participants and a soft robotic probe with controllable stiffness to access various levels of measurable information such as muscle co-contraction, change of speed and force, to test several hypotheses about the role of internal impedance in perception and action. Finally, we will use a human-robot collaborative physical examination task to test the effectiveness of a new soft robotic probe with controllable stiffness together with its stiffness and behaviour control algorithms. We will design and fabricate the novel soft robotic probe so that we can control the stiffness of its soft tissue in which sensors will be embedded to obtain embodied haptic perception. We will also design and fabricate a novel soft abdomen phantom with controllable stiffness internal organs to conduct palpation experiments. The innovation process of the above two designs - the novel probe and the abdomen phantom - will be done in collaboration with three leading industrial partners in the respective areas. The new insights will make a paradigm shift in the way we design soft robots that can share the controllable stiffness embodiment for both perception and action in a number of applications like remote medical interventions, robotic proxies in shopping, disaster response, games, museums, security screening, and manufacturing.

This project aims to deliver transformative advances in the development of nanoparticle constructs for use in precision surgery and beyond (e.g. therapeutic drug delivery). This will be achieved by bringing together experts with complimentary expertise in calixarene chemistry, nanochemistry, PET (positron emission tomography) imaging and surgical imaging. By developing the chemistry of calixarenes, we will optimize the galectin receptor binding affinity and demonstrate selective cancer cell targeting. Our preliminary studies reveal that radiolabelled (18F) 'Clicked' calixarenes are readily accessible, with improved HPLC purification (achieved via guest incorporation), which enables in vivo bio-distribution, highlighting ideal (renal) clearance. A major benefit of employing a calixarene-based scaffold is the ability for further functionalization. With this in mind, using standard protocols (Click chemistry), the calixarene will be further modified with the addition of a NOTA motif. The incorporation of such a strongly binding motif will allow us to develop the radiolabelling of this new platform technology, with maximum flexibility i.e. with both 18F and 68Ga radionuclides. The functionalized calixarene scaffold will be immobilized on luminescent conjugated polymer nanoparticles to enhance the imaging capabilities. The biodistribution and tumour uptake of the delivery platform will then be accessed (PET imaging), and results will be fed back into the synthetic programme to allow us to optimize the results. Following successful in vitro studies, in vivo tumour uptake will be assessed; tumour and organ uptake will be quantified to assess biodistribution and tumour targeting. The final phase of the project will explore opportunities for using this technology for the collection of spectra in vivo, by combining with a customizable dual camera head. To evaluate depth sensitivity and multimodal guidance an endoscopic gamma probe will be used for multi-functional probe identification. Such a combined approach will be suitable for pre-clinical imaging with a focus on high resolution and signal quality.