DANSER represents a multidisciplinary holistic and scientific based approach focused on the Danube River basin, a vital yet sensitive ecosystem facing climate change and human impacts. DANSER addresses pressing sediment management needs in the Danube River ecosystem, incorporating cutting-edge technologies and aligning with EU policies and directives. Especially attaining the core guidelines of the Danube Sediments Management Guidance. DANSER delivers a pilot phase and envisages the deployment phase, with a strong emphasis on demonstrating active and passive innovative solutions, such as a) spatio-temporal mapping of natural and anthropogenic fluvial processes, b) sediment transport modelling, (c) sediment dating by radionuclide and radiometric methods, d) historical pollution analysis (e) geophysical survey and 3D historical reconstruction of the demonstration sites, (f) river-groundwater dynamics and pollution transport modelling, (g) river processes forecast simulations based on historical and active processes, (h) sediment budget analysis based on sedimentation measuring stations, UAV and bathymetry surveys, (i) water levels and quality monitoring and analysis j) river-side arm hydrotechnical connectivity interventions, (k) stakeholder-engaged sediment parametric evaluation and co management and (l) Nature based solutions for biodiversity characterization monitoring and improvement. On the soft measures side, DANSER enforces proactively a transnational sediment task force, from cooperating with all related instances, and commits with local communities and citizens engagement, including participatory tools. DANSER seeks to restore sediment balance, improve sediment flow and quality, characterise pollution transport mechanisms and integrate such actions and knowledge with EU and worldwide counterparts while still sustaining local and regional economies. DANSER will contribute significantly to the create a sustainable and harmonious human-Danube relationships.