INSIDE-HEART brings together universities, companies and hospitals from countries (Italy, Finland, France, Israel, Netherlands, Spain, and Sweden) with the main scope of establishing a multi-disciplinary network to tackle the design and the early-phase validation of digital biomarkers, specifically targeting the diagnosis of supraventricular arrhythmias (SVAs) and their associated potential for adverse risk assessment, via the joint combination of signal processing, artificial intelligence and non-clinical devices. This will be achieved by performing excellent research through a unique doctoral training “without walls” among field-expert academic, industrial and clinical entities. The composite nature of the INSIDE-HEART network ensures a highly qualified training and research infrastructure for the specific goal, which aims to generate a new profile of researcher with multi-sectoral expertise able to fill the existing gap, i.e., the absence of digital biomarkers for SVAs reliably estimated with non-clinical devices, taking into account basic research, clinical needs and business interests. Research and training are designed to consider relevant aspects such as public concern of private data management, gender and ethics related to SVAs, all according to Responsible Research & Innovation principles and Open Science practices. All activities in INSIDE-HEART are designed to pursue innovation in three domains: i) Educational domain – by implementing a new multi-sectoral paradigm of PhD training to shape modern professional researchers with cross-competencies in the field, and able to accelerate the translation from basic science to market and clinics; ii) Basic science domain - by producing new knowledge about digital biomarkers by means of a multi-sectoral approach to explore the complex aspects related to SVAs; and iii) Technological domain – by developing new data-driven and model-based methodologies to compute digital biomarkers and support the clinical decision.

MASSTRPLAN will train the next generation of interdisciplinary research leaders in advanced molecular analytical techniques to detect oxidized phospholipids & proteins in biological & clinical samples, evaluate their biochemical roles in inflammation, and translate these findings to develop new diagnostic tools. Chronic inflammatory diseases such as diabetes, cardiovascular disease (CVD) & cancer are major causes of mortality and cost the EU economy dearly in healthcare and lost working time; CVD alone is estimated to be responsible for 47% of deaths and to cost the EU €196 billion a year. Scientists able to develop advanced analytical tools for detecting oxidative biomolecule modifications and assessing their contribution to cell dysfunction & disease are urgently needed. The objectives of MASSTRPLAN are to 1) train early stage researchers (ESRs) in advanced and novel chromatography, mass spectrometry, and complementary techniques including microscopy and bioinformatics to detect challenging heterogeneous biomolecule modifications and determine their functional effects; 2) give ESRs a broad perspective on relevance & mechanisms of oxidative modifications in pathophysiology and biotechnology; 3) enable ESRs trained in technology development to engage effectively with the clinical sector; and 4) train ESRs in translational and development skills to produce new protocols, materials and commercializable diagnostic tools. The ETN will achieve this by bringing together 10 beneficiaries and 15 partners from academic, industrial and healthcare organizations working in analytical, bioinformatic, biological, clinical & biotech fields to provide multidisciplinary, cross-sector training. Extensive mobility, industrial secondments and network-wide training will yield a cohort of analytical scientists with the unique theoretical, technological, and entrepreneurial skill set to yield new understanding of oxidative inflammatory disorders, leading to better tools and therapies.