The overall goal of the PREPARED project is to develop an operational ethics and integrity framework, which safeguards key ethical values, supports a rapid and effective research response to crises and improves overall pandemic preparedness. European Commission president Ursula von der Leyen outlined plans to cope with "an era of pandemics" by developing "Europe-wide fast-reaction system designed to respond more quickly to emerging medical threats". Fast reaction systems, including accelerated research, are likely to face significant ethics and integrity challenges. The PREPARED project will create an international network of research funders (private and public), researchers, policy makers, publishers and citizens (a) to identify, analyse and validate the emergent research ethics and integrity challenges in the context of sudden, unexpected and global crisis, (b) to facilitate bottom-up, solution-focused, participatory dialogue, (c) to develop a values-based framework for research ethics and integrity in a global crisis which supports rapid and effective decision-making whilst maintaining scientific reliability and avoiding short-cuts in the protection of research participants, (d) to propose policy options at the EU level and tailored support for relevant stakeholders in the form of operational guidelines and short complements to existing codes and (e) to achieve influential strategic engagement through high-level synergy building and the provision of engaging training material to ensure uptake of the project's outputs so as to improve overall preparedness for global crises. Given that this is a Coordination and Support Action, the high-level consortium consists to 47% of research institutions (given that this is a CSA) and to 53% of organisations which can significantly contribute to and then leverage results (e.g. UNESCO, EDCTP, RIS).

ADAM^2 aims at questioning five decades of traditional paradigms in computer aided design CAD. While the field of CAD has been very successful in the last half a century using boundary representations, the introduction of microstructure into the design-analysis-manufacturing cycle is going to completely revolutionize geometric CAD from the ground up and into the essential volumetric representations, making an unprecedented leap in the quality of manufactured artefact. The evolution of new manufacturing technologies such as multi-material 3D printers gives rise to new type of objects that may consist of considerably less, yet heterogeneous, material, consequently being porous, lighter and cheaper, while having the very same functionality (e.g. stiffness) as the original object when manufactured from one single solid material. We propose a unified manufacturing pipeline that will focus on all stages involving Analysis, Design, And Manufacturing using Microstructures (ADAM^2). ADAM^2 proposes high-risky interdisciplinary research that will combine user-guided shape modelling using microstructures, followed by validation and structural optimization using physical process simulation, and finalized by physical realizations via additive and hybrid manufacturing and its subsequent validation. The results of this project will lead to scientific-technological development that impacts €2B/year CAD and €24B/year tool manufacturing European markets, and are expected to reduce the exploitation of heavy materials between an order of magnitude to two orders, in volume.