Fundamental changes occurred in the study of nature between the late 15th and 18th centuries, leading to the emergence of modern science as we know it. This process would have been impossible without Latin as the scientific lingua franca of the era, just as today's science is hard to imagine without English. At present, this crucial role of Latin is insufficiently acknowledged, and the hundreds of thousands of scientific texts written in Latin have largely remained neglected. This severely limits the scope of research into the history of early modern science, an otherwise thriving field. The proposed project intends to decisively advance our understanding of the interrelation of Latin and science in early modern times. By applying the methods of Latin philology, yet at the same time reaching out to historians of science, it will establish early modern scientific literature in Latin as an interdisciplinary research field. This will be accomplished (a) by examining and classifying the formal variety and range of content of this literature to create an overall picture (b) by analysing its function as a medium of communication within and beyond the scientific community. To realise the first of these objectives, a tripartite database for authors, early modern texts, and secondary literature will be compiled and a sourcebook with a selection of digitally searchable texts put together, both of which will be made available online. A monograph will provide an overview structured according to the literary genres of early modern scientific literature in Latin. The second objective will be achieved through a series of interlinked monographs, whose analyses will build on the system of ancient rhetoric, the most important communicative paradigm of the early modern age. On this basis, four key functions of Latin scientific texts will be assessed: naming new phenomena; describing and explaining them; convincing others of the views expressed; and promoting science.

In the EU alone, according to the Orphanet DB (https://pubmed.ncbi.nlm.nih.gov/31527858/), 30 million persons, 3,5-6% of the general population, are affected by one of the 6,172 different rare diseases (RDs) of which 72% are genetic and 70% affect children. The path to diagnosis for people suffering from a RD is burdensome, often severely delayed by a diagnostic odyssey. Lack of timely diagnosis affects disease management, family planning, identification of potential beneficial treatments and / or clinical trials. This unacceptable situation does not meet the concept of equity for EU citizens, and requires rapid, structured, and cost-effective corrective actions. The Screen4Care (S4C) consortium will leverage the genomic and digital advent to develop and pilot genetic NBS and AI-guided symptom recognition algorithms, while accounting for all relevant legal, regulatory and ethical considerations. S4C aims to harmonize the results of existing efforts in a horizon scan, by looking at the totality of the available data resources, diagnostic algorithms, and other initiatives with similar ultimate goals. The genetic NBS will interrogate 1) currently treatable RDs (TREAT-map gene panel), 2) actionable RDs (ACT-map gene panel) in 18.000 new-borns in 3 EU countries (D, It, and Cz). Further, S4C will offer whole genome sequencing (WGS) to early symptomatic babies, tested negatively during panel-based NBS to identify known NBS-escaped RDs and novel genes/phenotypes. S4C will also provide two digital diagnosis support systems for RD on the basis of features and symptom complexes: 1) federated ML- and literature-evidence-based algorithm for continuous and automated screening of EHR and 2) meta symptom checker with virtual clinics for patients and HCP offering the possibility of increased accuracy of diagnosis and ongoing supports. Our ambitious goal is to evaluate the validity of our multi-pronged approach to shorten the time to diagnosis for all patients affect by RDs, improve value-based healthcare resource utilization, and hopefully reduce the suffering of millions of European citizens.

The current pandemic has highlighted an increased need for active citizenship and regional as well as global cooperation. At the same time, it provides us with an opportunity toreassess our old practices and take a set of bolder measures in order to prevent future crises which can be far more devastating than the current one, such as climate change andexacerbating inequalities. The partners of this project are thus convinced that an increasing number of people need to be directly involved in the conscious shaping of our common future. This process will need well-informed citizens showing a capacity to imagine a better future and able to look at different alternatives with both open and critical minds. In particular young people play an important role in this regard as they are receptive to new approaches and can act as multipliers for innovative participation instruments.This partnership thus aims to create an “EU Democracy Rally” providing young people with the opportunity to train their active citizenship skills while jointly building political and social campaigns. The online participation platform democracyrally.eu will feature an online version of the Rally and enable participants to team up on the European level while cooperating with youth workers as well as decision- and change-makers. A third intellectual output will be a toolkit allowing young people to explore the democracy of the future, including mind games, simulations, studies and joint exploration activities.This strategic partnership includes ten partners from ten EU countries who each possess specific expertise on matters related to active citizenship, including decision-makingprocesses, EU participation instruments, human rights education, open data and open cities, investigative journalism, game-based learning, team management and intercultural skills, fact checking, mental and digital well-being, law reform and transparency, and the development of creativity.Partners will meet five times in the course of the project during transnational partner meetings in order to jointly develop their future participation instruments. One Learning, Teaching and Training Activity will give partners the opportunity to test their developed participation instruments with a European group of young participants. Partners will also organise an online conference on future democracy with the aim of exploring the most advanced and most promising democratic processes existing all over the planet. Finally, partners will organise two multiplier events in Luxembourg and Brussels.Partners will use a hybrid project management methodology combining the Waterfall and Agile methodologies. Initially, this methodology focuses on gathering and analysingrequirements while defining clear responsibilities. In the course of the project, the agile management component grants partners the necessary freedom to experiment with new approaches and gradually expand the scope of project activities.Apart from the three main outputs, partners will also set up local, regional, national and European implementation teams for their created instruments: the EU Democracy Rally and exploration activities on future democracy. An online exchange database created on their common website will enable every institution or youth worker implementing the tool to register and benefit from the support of the partnership during the implementation of the Democracy Rally and related youth campaigns developed by participants.The developed tools will thus support youth workers all over the EU in boosting active citizenship skills of young people. Young people will further be empowered by teaming up on a European level in order to give greater leverage to their political and social campaigns developed in the course of the EU Democracy Rally. Young people at risk of exclusion will feel empowered by the experience of cooperating with their peers while jointly creating initiatives which have an impact on social and political challenges they feel strongly about.By connecting young people from all over Europe with decision- and change-makers, the platform will create a feedback loop between these stakeholders and foster their constant dialogue in view of jointly identifying solutions to local, regional and European challenges.The online platform will further serve as a reference tool for the exploration of democratic innovations, in particular with regard to the political development of the European Union.Finally, the exploration activities on future democracy will help to sensitise young people, youth workers, policy- and change-makers to the potentialities of future democraticparticipation mechanisms. Partners are convinced that democratic innovation will play a fundamental role in the process of tackling global challenges and finding more sustainable lifestyles. As a space protecting fundamental human values and freedoms, the European Union can play a decisive role in this process.

The evidence base of Internet-based interventions in the prevention and treatment of mental health conditions has rapidly grown in the past decade. Yet many European countries (e.g., Germany, Austria, Switzerland, Great Britain, The Netherlands, Spain) have not implemented these promising approaches into health systems. Individuals with risk conditions or distinct mental health problems interested in using online interventions are often unable to access appropriate and evidence-based online interventions. The aim of this proposal is to establish a comprehensive model of health promotion, risk detection, disease prevention, and treatment facilitation for the most prevalent mental health problems and disorders (depression, anxiety, adjustment disorders, eating disorders/weight management and substance abuse) that assists individuals and mental health professionals in selecting and using evidence-based, online interventions. To reach this aim, the project partners bring together over 30 evidence-based, online interventions spanning the mental health intervention spectrum from universal and targeted prevention, self-help to treatment for the respective conditions applicable to children, adolescents and adults. Following a stakeholder needs survey, the model will be integrated into existing health care and other settings in Germany, Great Britain, Switzerland, Austria, The Netherlands, and Spain by 1. developing valid and economic, online screenings to allocate individuals to interventions, 2. developing technology for a common e-Health intervention platform, 3. developing implementation plans, 4. implementing evidence-based interventions into health care, and 5. evaluating and comparing their feasibility, acceptability, reach, efficacy and (cost)-effectiveness, adoption, and dissemination including moderators of interventions. Our proposal aims at the sustained implementation of the ICare model into health services and collaborations with health care providers across different EU countries.