CHV
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8 Projects, page 1 of 2
assignment_turned_in Project2015 - 2018Partners:Centre Hospitalier Universitaire de Poitiers, CHV, INSERM U1082Centre Hospitalier Universitaire de Poitiers,CHV,INSERM U1082Funder: Institut National du Cancer Project Code: INCa-8658more_vert assignment_turned_in ProjectPartners:Hôpital Morvan, Centre Eugène Marquis, Institut Gustave Roussy, Université de Franche-Comté, Hôpital Hôtel-Dieu +5 partnersHôpital Morvan,Centre Eugène Marquis,Institut Gustave Roussy,Université de Franche-Comté,Hôpital Hôtel-Dieu,CHV,Institut Curie,Hôpital Nord,CHU Dijon-Bourgogne - Centre Hospitalier Universitaire de Dijon,Centre Georges-François LeclercFunder: Institut National du Cancer Project Code: INCa-DGOS-11128more_vert assignment_turned_in ProjectPartners:Institut Bergonié, ICM-VAL D'AURELLE, Institut Gustave Roussy, Centre Léon Bérard, Hôpital Jean Minjoz +10 partnersInstitut Bergonié,ICM-VAL D'AURELLE,Institut Gustave Roussy,Centre Léon Bérard,Hôpital Jean Minjoz,Centre Hospitalier de Mont-de-Marsan,Centre Hospitalier Universitaire de Nîmes,Institut de cancérologie Lucien Neuwirth,Centre François Baclesse,CHV,Centre René Gauducheau,Centre Georges-François Leclerc,Institut de Cancérologie de l'Ouest,Institut Claudius Regaud,Hôpital Saint-LouisFunder: Institut National du Cancer Project Code: INCa-DGOS-5424more_vert assignment_turned_in ProjectPartners:CHVCHVFunder: Institut National du Cancer Project Code: INCa-DGOS-8599more_vert - UVSQ,INRAE,VIM,VALOTEC,CHV,University of Paris-Saclay,RUBIX,Université Paris-CitéFunder: French National Research Agency (ANR) Project Code: ANR-22-CE52-0014Funder Contribution: 567,861 EUR
While blindness and deafness are widely recognized by the medical community and the society, permanent loss of smell (anosmia), despite being frequent (5% of the global population), deeply altering the quality of life (loss of appetite, social distress) and causing numerous health issues (household hazards, depression, death), did not benefit from much consideration before the COVID-19 pandemic. This disease dramatically increased the incidence of olfactory dysfunction, which is encountered in more than 60% of cases. If most patients recover in a few weeks, about 5 % have still not recovered. Until now, olfactory training has been the only treatment associated with significant benefits for smell recovery, but did not benefit all the patients. Moreover, it is restricted to post-viral anosmia, and there’s currently no treatment for long-lasting anosmia. The DOLFINA project aims to develop an olfactory implant, based on the same concept as the cochlear implant, which has been successfully used to treat patients suffering from deafness. Firstly, we propose to develop sets of electrical stimulation of the olfactory bulb in a rat model that mimics the odorant driven activation of olfactory processing structures by different odorants. Then, we will develop an odorant sensor (electronic nose) able to transform the detection of a given odorant into a specific electrical stimulation. Finally, we will validate the olfactory implant in a rat model, then test it in a sheep model, which is anatomically closer to humans, before its future implementation for the first time in an anosmic patient.
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