GENDER STI will innovatively contribute to solve complex problems associated to the integration of the gender perspective in STI dialogues with third countries. By adopting a design thinking human-centric problem-solving approach, GENDER STI will investigate how gender equality is taken into consideration at different levels of international cooperation dialogues in the area of STI, between the EU Member States and Associated Countries, and a selected set of 10 third countries, including Canada, the United States, Mexico, Brazil, Chile, Argentina, South Africa, India, South Korea and China. This one of a kind consortium of EU and third countries partners will have a meaningful impact in accelerating the integration of gender equality in STI dialogues with third countries. The investigation will be conducted along the three objectives of the Gender Equality strategy in EU R&I, i.e. gender equality in scientific careers, gender in decision making, and gender in R&I content. Built on the work done by ERA-related groups on gender equality and international cooperation, as well as EU funded projects, GENDER STI will provide a mapping and comparative analysis on gender equality in STI bilateral and multilateral agreements with the selected third countries. In addition, the project will deploy a series of Co-Design Lab workshops to create the environment to co-design solutions regarding gender inequalities in STI dialogues. As a result, the project will create the GENDER STI Community of Practice that will help to scale up the experience of gender equality in STI at a European and international level, and the European Observatory on Gender in STI, which is unique of its kind in Europe and will serve as a hub for gender equality in STI dialogues, incorporating all knowledge and materials resulting from the project. These actionable insights will feed the process to formulate recommendations to enhance the integration of gender equality in STI dialogues with third countries.