The high stability of components like cellulose limit the efficiency and cost effectiveness of biofuel or chemical production from lignocellulosic biomass. Thus, the ability of the recently discovered class of metalloenzymes, lytic polysaccharide monooxygenases (LPMO), to enhance the efficiency of recalcitrant polysaccharide degradation makes understanding these enzymes invaluable for carbon friendly sustainable chemical and energy development as prioritized under the Horizon2020 program. The current project seeks to develop multi-layered biomimetics of the LPMO active site that can offer unprecedented replication first and second coordination sphere groups, in order to be able to rationally study the collection of interactions that contribute to enzyme activity. The research involves the design and chemical synthesis of aromatic oligoamide scaffolds that incorporate a specific copper binding site. Through synthetic modification of the scaffold to alter the second coordination sphere, and combined spectroscopic and electrochemical methods, changes in the properties and reactivity of the metal site will be studied with a goal of developing a structure- function relationship that can assist in guiding enzyme modification, as well as, new synthetic catalyst development. The applicant has a strong background in synthetic chemistry and mechanistic studies that will be crucial to the success of the project. Through joining the host lab in Belgium that specializes in coordination and supramolecular chemistry, she will greatly increase her own knowledge base, while transferring her knowledge of synthetic organic chemistry to the host. Additionally, during proposed secondments to work with a collaborator in Germany for the electrochemical studies, the applicant will further expand the gain and transfer of knowledge and strengthen international collaboration between the groups involved.

The OTCT project will build on the results and recommendations of the OPTIMALE network, an Erasmus Academic Network of 70 academic and language industry partners in the field of professional translation. The OPTIMALE online survey of language industry employers’ competence requirements showed that awareness of and the ability to implement professional procedures throughout the translation process are key factors in the employability of university translation graduates. This led to the definition of good practice in specific areas of translator training, in particular in the integration of professionally-oriented practices in the curriculum.The OTCT project (Optimising Translator Training through Collaborative Technical Translation) aims to enhance the professionally-oriented content of university translation degree programmes via intensive collaborative technical translation sessions in simulated professional conditions (referred to as “Tradutech sessions”), and by exchanging good practice and resources on the implementation of project-based teaching and learning in the field of translator training.The project will involve students and staff in advanced translation degree programmes from seven academic institutions (Rennes 2 University, France; HE Vinci, Brussels, Belgium; Swansea University, UK; Univerzita Karlova V Praze, Prague, Czech Republic; Universitatea Babes-Bolyai, Cluj-Napoca, Romania; Universita ta Malta, Malta; Universidad Pablo de Olavide, Sevilla, Spain). It will primarily involve 1st and/or 2nd year Master’s degree students (i.e. 20-80 students in each institution) but may also involve students in the final year of Bachelor’s degree programmes where relevant (i.e. Sevilla). Two to three members of the teaching staff from each institution will be directly involved, but a larger number will benefit from the outcomes of the project.The project will center on the “Tradutech” intensive sessions, with preparatory activities leading up to the sessions and material from the sessions feeding into further resources for use in the classroom. Four “Tradutech” sessions will take place during the project. Each five-day session will involve students setting up simulated translation companies (i.e. teams of 5-10 students, with specific responsibilities and roles assigned to each team member), who will then carry out large-scale multilingual technical translation projects according to the specifications and deadlines set by their “clients”. Source documents will be authentic technical manuals, reports or multimedia materials which will be translated into the main target language(s) of the partner institutions. The source documents will be in English or French as the case may be. Projects will be managed in turn by students from each partner institution, using collaborative software to exchange resource materials and files and computer-assisted translation software to carry out the translations. Prior to the Tradutech sessions, students will receive training in technical translation, project management, quality control and translation technologies, using resources produced by different partner institutions and shared with the other partners within the project. Participants will be briefed on the conditions and implementation of the Tradutech sessions, using tutorials produced by students from Rennes and Cluj with prior experience of such sessions. A joint terminology project will involve students from all the partner institutions, in order to promote cooperation and familiarize them with the use of the collaborative platform set up for the project. Output from the student “translation companies” will be assessed according to professional criteria by language industry professionals and feedback will be provided to the students and used as learning materials in classes following the Tradutech sessions. All students who have completed a Tradutech session (i.e. have successfully carried out the responsibilities and tasks allocated to them within one or several translation projects) and the preparatory work prior to the session, will be awarded 4 ECTS credits as part of their study programme.Two of Rennes Tradutech sessions will be attended by teaching staff from the other partner institutions, who will take part in a parallel training of trainer session. Two other sessions will be attended by students from the other institutions, who will be integrated as full members of the Rennes teams.Sustainability will be ensured by teaching and learning resource production and dissemination, the training of trainer sessions, and the production of a Handbook on the implementation of project-based translator training which will be made freely available to other institutions. Participating students will benefit from the hands-on experience and professional feedback, while teaching staff will gain experience of project-based collaborative learning methodologies.

Sweet Crosstalk is a multidisciplinary European Training Network built to address the challenge of understanding, at a molecular level, how glycans are involved at the human mucosa–microbiota interface, and how this correlates with human well-being. Research into the human microbiome has reshaped the paradigm of our health and disease. In order to advance further, the time has arrived to understand it at a molecular level. Glycans dominate the microbiota-host interface and are thus ideally positioned to modulate these complex interactions. The research strategy of the Sweet Crosstalk programme focuses on optimal synergy between chemistry and biology. Smart chemistry drives the research to get a molecular-level grip on the role of these glycocodes and their interacting proteins, and advances in biology directs the research. The high quality and credibility of our consortium is ensured by a strong private-public partnership with complementary expertise ranging from chemical synthesis, biochemistry, structural biology to microbiology and cell biology. Our 7 academic groups are all renowned leaders in the glycoscience and microbiome fields, whereas the complementary 4 SMEs are specialized in glycan-based diagnostics and prophylactic therapies. This unique combination of scientific excellence and industry know-how covers the entire process from obtaining fundamental insight to the development of innovative early diagnostics and glycotherapeutics. Sweet Crosstalk also represents a unique research platform to train 15 outstanding Early Stage Researchers to be the new generation of innovative scientists with expert knowledge and skills in interdisciplinary glycoscience and human microbiome research. Our international, intersectoral and interdisciplinary training programme will equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the healthcare/biotech job market.

Inorganic crystalline materials promise solutions to some of our major global problems. Thermoelectric materials, for example, are expected to increase the energy efficiency of many electric devices or production sites to lower the global need for energy. To arrive at materials with properties relevant for thermoelectric applications, a better understanding of structure-property relationships could play a key role. Linus Pauling’s famous five rules on the stability of crystal structures will serve as a starting point for such an improved understanding because they describe the relation between structure and stability based on coordination polyhedra and their connections. They will be assessed for oxides and other chemistries. This will be based on the Materials Project database and a recent study of the statistics of coordination environments in oxides from the host institute. Next, a graph representation of crystal structures based on coordination polyhedra and their connections will be established to go beyond Pauling’s rules. The graphs will then be analysed and classified. Beyond stability, there is a recent design principle relating coordination polyhedra to lattice thermal conductivity–an essential property for thermoelectrics. It will be applied to search for oxides as potential candidates for thermoelectric applications. The design principle is based on the instability of small cations in octahedral coordination environments that is connected to low thermal conductivity. The recent development of one of the first databases of phonon computations at the host institute offers a great opportunity to link phonon and especially soft modes to coordination environments. The best candidates from the search will be synthesized and analysed by a cooperation partner of the host institute. In sum, the project is expected to lead to a better understanding of coordination polyhedra, their connections, and their relation to the stability and other properties of crystals.

The TROPICO project (Transforming into Open, Innovative and Collaborative Governments) aims to comparatively examine how public administrations are transformed to enhance collaboration in policy design and service delivery, advancing the participation of public, private and societal actors. It will analyse collaboration in and by governments, with a special emphasis on the use of information and communication technologies (ICT), and its consequences. Assessing the institutional conditions and individual drivers and barriers is crucial for understanding the transformation of governments towards greater collaboration. The state structures and administrative traditions provide different 'starting points' of the public sectors in Europe. Likewise, individual attitudes, skills, and expertise of officials play a decisive role in understanding this transformation. Subsequently, TROPICO will examine collaboration practices within governments (internal) and between public, private and societal actors (external), across a variety of policy sectors. We will study the actors and means of innovative collaboration, including ICT, and how they are interlinked. Lastly, assessing the effects of collaboration for legitimacy, accountability and government efficiency is essential to provide a comprehensive analysis of the transformation towards open, innovative, and collaborative governments. Our multidisciplinary project will follow a truly comparative approach, examining ten countries representing the five administrative traditions in Europe: Nordic (Norway, Denmark), Central and Eastern European (Estonia, Hungary), Continental (Netherlands, Germany), Napoleonic (France, Spain; Belgium (mixed)), and Anglo-Saxon (United Kingdom). We will combine rigorous quantitative and qualitative research methods. TROPICO puts a strong emphasis on the inclusion of stakeholders and users throughout the project to test and reflect upon the applicability of our key findings and policy recommendations.