University of Bari Aldo Moro
University of Bari Aldo Moro
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119 Projects, page 1 of 24
Open Access Mandate for Publications and Research data assignment_turned_in Project2018 - 2021Partners:University of Bari Aldo MoroUniversity of Bari Aldo MoroFunder: European Commission Project Code: 798181Overall Budget: 262,269 EURFunder Contribution: 262,269 EURSchizophrenia risk is largely determined by genetic variation and is associated with altered development of several brain regions. Since there are likely thousands of genetic risk variants, the biology of risk and its effects on neural development cannot be determined by examining one gene at a time. Rather, it is important to understand how these genes converge into molecular pathways that determine overall risk. Genes converge into pathways because they are coordinated in response to environmental and physiologic factors. Hence, FLOURISH aims to identify biologically plausible pathways of convergence of genetic risk for schizophrenia along neural development in critical brain regions involved in schizophrenia risk. Gene Co-expression Network Analysis is effective to identify pathways of genes that are regulated, and thus expressed, together. FLOURISH will study how gene co-expression unfolds along the lifespan in the prefrontal cortex, hippocampus and striatum. Gene co-expression networks will then be associated with genetic variants to identify markers of pathway co-regulation. Genetic markers of pathways co-regulation will be combined into polygenic scores that will be tested as predictors of the structure and activity of the target brain regions assessed by magnetic resonance imaging. The action will consist of a training period (2 years) which Dr. Giulio Pergola will spend at the Lieber Institute for Brain Development (LIBD) at Johns Hopkins University, Baltimore, USA. LIBD is unique because of the unrivalled technology, expertise and research data regarding brain development. Dr. Pergola will be training about RNA analyses and return to the University of Bari Aldo Moro (UNIBA) in the final year, to validate his genetic discoveries by means of neuroimaging. UNIBA is currently setting up the largest neuroimaging center in southern Italy and plans to have Dr. Pergola build an imaging genomics team to promote personalized medicine in psychiatry.
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For further information contact us at helpdesk@openaire.euOpen Access Mandate for Publications and Research data assignment_turned_in Project2023 - 2025Partners:University of Bari Aldo MoroUniversity of Bari Aldo MoroFunder: European Commission Project Code: 101106497Funder Contribution: 172,750 EURWith ever-increasing costs for the development of new drugs, the call for the development of more cost-effective and efficient methodologies to streamline the access to new drug candidates is imperative. To access new chemical space, the ring-distortion strategy – late-stage modification of rings to a variety of different functionalized cyclic and acyclic motifs – has proven a particularly successful approach. Recently, numerous ring-expansion and functionalisation protocols to cyclopentanones, tetralones, γ-functionalized butanones from cyclobutanols have been developed using classical batch processes. Despite the advances, the translation to pharmaceutically relevant applications is still outstanding; mainly due to three factors: 1)The application of heterocycles in these protocols has been very limited or even impossible 2)The two-carbon ring expansion has only been successful on aryl-substituted analogues, yet not on alkene-substituted analogues & 3)Scale-up to practical quantities is often difficult due to the requirement for conditions difficult to realise using batch processing. Expand Flow presents a multidisciplinary project that lies in the intersection of flash chemistry and synthetic photo-catalysis with microfluidic engineering and computational chemistry for the development of a selective, sustainable and applicable methodology for the ring deconstruction and functionalisation of heterocycles. Ultimately, its applicability to the pharmaceutical industry will be proven by the total synthesis of THC and its hitherto unexplored heterocyclic analogues. Overall, this project will add a valuable tool to the synthetic chemist’s repertoire for the rapid, environmentally-friendly and cost-effective development of new drug candidates by the versatile functionalisation of various heterocycles. This innovative approach will have a high scientific, technological and societal impact, reinforcing the European competitiveness in the development of life-saving drugs.
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For further information contact us at helpdesk@openaire.euOpen Access Mandate for Publications and Research data assignment_turned_in Project2026 - 2028Partners:University of Bari Aldo MoroUniversity of Bari Aldo MoroFunder: European Commission Project Code: 101204182Funder Contribution: 193,643 EURAlthough the rise of artificial intelligence technology greatly benefits our life by improving work productivity, the increasingly high energy consumption required to operate these software programs to cope with huge computational tasks becomes a serious issue. This is mainly due to inefficient data transport between separated memory and computing units (von Neumann bottleneck) in traditional computers. To minimize energy cost while maintaining computing power, this MSCA-PF research project - MoleSynap - aims to design brain-inspired electronic devices. Specifically, MoleSynap will fabricate artificial synapses by emulating biological synapses. These artificial synaptic devices will be designed in three-terminal transistor configuration (synaptic transistors), given their excellent regulation of charge carrier flow during device operation. Current organic polymer-based synaptic transistors suffer from the decreasing long-term device accuracy and high device-to-device variations, mainly due to nonperfect active-layers thin-films prepared by traditional solution-based wet methods. In this regard, MoleSynap will go beyond the current state-of-the-art on two different levels: (1) employ emerging two-dimensional coordination polymers and ionogel electrolytes as active-layer materials for improving synaptic characteristics, and (2) develop all-dry solvent-free thin-film deposition technology to fabricate active-layer thin-films with high precision and consistency. Overall, MoleSynap aims to significantly advance the field in developing organic synaptic devices for low-energy-cost computing. Moreover, MoleSynap will lay the strong foundation for building my own research group, and fulfill my long term scientific goal of bridging basic science (fundamental polymer physics) and applied science (polymer electronics devices) in polymer materials to promote environmental sustainability.
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For further information contact us at helpdesk@openaire.euOpen Access Mandate for Publications assignment_turned_in Project2022 - 2024Partners:University of Bari Aldo MoroUniversity of Bari Aldo MoroFunder: European Commission Project Code: 101031186Overall Budget: 171,473 EURFunder Contribution: 171,473 EURThe development of synthetic plastics has changed our world and currently several types of plastics are found in different applications. Most of the plastics comes from fossil resources and they are non-biodegradable materials causing a serious threat for the environment. Bioplastics are mostly produced from food resources which are not sustainable. For these reasons, the solution can be the use of waste. REWIND aims at the valorization of waste products through their enzymatic transformation following a circular economy approach. The production of monomers and polymers will be capitalized through the test of different recombinantly produced enzymes. The enzymatic transformations will be tested using single enzymes or a cocktail of biocatalysts (either free or immobilized) to identify the potential of the biocatalytic cascade. The use of enzymes, and their further engineering, will reduce the utilization of harsh reaction conditions and chemicals, such as organic solvents and metal catalysts. The produced bioplastics will be tested in terms of thermal and mechanical properties. In order to test their sustainability and impact on the environment, degradation tests in the presence of different environmental conditions (pH, Temperature and pressure) and with biological factors (enzymes and microorganisms) will be assayed. Sustainability assessment of the process and the products’ life will identify the steps that could be improved to reduce the impact. The researcher, who already possesses sound knowledge and skills in biocatalysis, will gain more knowledge in polymer chemistry and material characterization through the attendance of hand-on courses and collaborations with polymer chemists. Entrepreneurship and patent writing courses will increase the innovative mindset of the researcher for a better society. The results of the project will be disseminated both in the academic and non-academic sectors. The researcher will engage public communication.
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For further information contact us at helpdesk@openaire.euOpen Access Mandate for Publications and Research data assignment_turned_in Project2022 - 2027Partners:Åbo Akademi University, University of Bari Aldo MoroÅbo Akademi University,University of Bari Aldo MoroFunder: European Commission Project Code: 101040383Overall Budget: 2,499,580 EURFunder Contribution: 2,499,580 EURBiomarkers are measurable indicators of a particular disease state of an organism. There has been an increasing demand for diagnostic markers, enabling reliable and non-invasive screening of peripheral biofluids. It is also established that a universal screening against life-threatening diseases, such as cancer, or infectious disease outbreaks, can be accomplished only by combining genomic and protein marker-based tests. The NoOne project aims at conceiving, engineering, fabricating and validating a ground-breaking platform based on a single-molecule binary bioelectronic sensor, capable to reliably discriminate biofluid samples enclosing zero biomarkers from those containing just one. The technology can be used for ultimate binary sensing of both proteins/peptides and genomic markers to enable the reliable screening of diseases such as cancer as well as viral and bacterial infections. The NoOne binary platform is designed to be portable, cost-effective, easy to operate and with a time-to-results within one hour; hence it is the ideal candidate for point-of-care applications. The prototype will enable clinicians, phytopathologists or veterinaries, to identify the set of samples that are totally free from a protein, peptide or genomic marker as well as from a pathogen (virus or bacteria), from those enclosing at least one with a confidence level of 99%. This makes the NoOne platform the best performing ever in enabling a fast, highly reliable, cost-effective identification of the subset of biological samples belonging to the potentially diseased part of a population. This is of paramount importance for predictive screening of humans, plants or animals. NoOne will demonstrate its effectiveness in key relevant applications such as the binary detection of pancreatic cancer biomarkers, SARS-CoV-2 virus, the Xylella Fastidiosa bacterium and the assay of post translational peptides evidencing the phosphorylated forms regulating crosstalk with oncogenic signalling pathways.
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