Our project “Enhanced networking on antimicrobial resistance surveillance with NGS” brings together Semmelweis University (SU) and Klinika Za Infektivne Bolesti „Dr. Fran Mihaljevic (BFM) with two internationally leading research institutions, Laboratory of Medical Microbiology (LMM), University of Antwerp (UAntwerp) and the Health Research Institute of the Balearic Islands (IdISBa) , on the topic of Antimicrobial resistance surveillance with whole genome sequencing (WGS) in correlation next-generation sequencing techniques. Our aim in AmReSu is to strengthen, to the highest European level, Semmelweis University (SU)’s and Klinika Za Infektivne Bolesti „Dr. Fran Mihaljevic” (BFM)’s scientific excellence and innovation capacity in Antimicrobial resistance surveillance and to set-up an ‘Antimicrobial resistance surveillance vision’ in Hungary and Croatia. Strenghtening antimicrobial resistance (AMR) surveillance is also in line with the Hungarian National Smart Specialisation Strategy and the Croatian National Programe for Antibiotic Resistance Control. AMR bacterial infections are a global threat, they are responsible for increased morbidity and mortality rates in Hungary and Croatia, especially in cases of nosocomial infection. Many previously manageable bacterial infections are becoming increasingly hard to treat. Rising rates of resistance amplify the morbidity and economic burden associated with infections. An estimated 700,000 deaths attributable to AMR every year in the world, and a projected 10 million deaths per year by 2050 in the absence of additional control measures. The core activities of our project are knowledge transfer, exchanges of best practices via a number of institutional networking and training activities, including workshops, conferences, summer schools. to a new level, promoting research excellence in AMR and Microbiome with strong societal impact. Our proposed actions will strengthen joint research programmes in Europe.

Over 30% of EU citizens at vulnerable stages and situations in life are at increased risk to transgress from healthy weight to overweight and further to obesity. Though many interventions to tackle obesity have been proposed, they have rarely been effective. The aim of HealthyW8 is to advance the efficacy of current and future efforts and investments in obesity prevention initiatives across Europe. Most interventions suffer from not adapting to personal context (e.g. socioeconomic aspects, host-biological factors, environment, dietary preferences, fitness level etc.), focus only on diet or physical activity alone, do especially overlook emotional aspects, and fail to engage and motivate the user. Thus, initiatives on obesity prevention in policy and practice are often of marginal impact. HealthyW8 will address these shortcomings by iteratively developing, together with stakeholders, a digital-based healthy lifestyle recommender for evidence-based, tailored interventions and tools including a human digital twin to bridge the gap between science, societal actors and stakeholders (e.g. healthcare professionals, food industries, policymakers) and EU citizens. The targeted populations are those undergoing transitions, i.e. schoolchildren (5-10 y, and their parents), young adults (18-25 y) and the elderly (>65 y). In the mid-term, we estimate that with 200,000 HealthyW8 users, we will prevent 10,000 obesity cases/y. In the long run, the impact will be maximized through adopting the project’s proposed methodology, platform and tools by as many EU institutions and entities as possible. HealthyW8 is a highly experienced, synergistic and complementary consortium that will built on a previously developed digital dietary app (LIFANA) and draw on transdisciplinary research in pan-EU multicentre pilots and long-term randomized control trials to achieve its overarching objective of increasing impact of current and future obesity prevention interventions and policies in the EU.