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282 Projects, page 1 of 57

  • MICEPAS MIR-EC-QCL (Novel miniaturized photoacoustic cell integrated with compact mid-infrared widely-tunable laser for gas-detection applications)

    assignment_turned_inProject2014 - 2016Partners:HU
    Funder: European Commission Project Code: 625248
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  • IMAGING COLUMNS (State dependent flow of excitation and activation of inhibition in cortical columns)

    assignment_turned_inProject2014 - 2016Partners:HU
    Funder: European Commission Project Code: 628720
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  • DENDRITE2BEHAVIOR (From dendrite to behavior: fiberoptic Imaging and optogenetic manipulation of dendritic activity in behaving animals)

    assignment_turned_inProject2013 - 2015Partners:HU
    Funder: European Commission Project Code: 329316
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  • MOLECULARDOCTORS (RNA-codified release of cytotoxic peptides from PNA prodrugs as a new therapeutic approach to cancer)

    assignment_turned_inProject2011 - 2013Partners:HU
    Funder: European Commission Project Code: 273051
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  • MECHPREDPRO (Cellular mechanisms of predictive processing and its effects on perception)

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Open Access Mandate for Publications and Research data assignment_turned_inProject2018 - 2020Partners:HU
    Funder: European Commission Project Code: 799411
    Overall Budget: 171,461 EURFunder Contribution: 171,461 EUR

    Predictive processing is a leading theory of brain function. However, despite several conjectures it is unknown how predictive processing is implemented at the neural level. We will try to understand the exact role of the computations of the layer 5 pyramidal (L5p) cells within the framework of predictive processing. The experimental paradigm and the computational model used here are designed to answer, whether L5p cells carry predictions, as the theory of predictive processing suggests, or are they responsible for some other computation. To this end we will a) adapt experimental paradigms used with humans to study probabilistic computations in the mouse model, b) measure the dendritic input and somatic output of L5p cells in mice, c) capture this activity with computational models and d) manipulate the apical dendritic input and somatic output of L5p through noradrenaline antagonists. The project allows us to understand the mechanisms underlying predictions and their effect on perception.

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