The aim of this Project is to design, in the European higher education field, a joint educational offer, at Master's level, in which, through a Consortium, 4 European higher education institutions and another 4 higher education institutions of third countries not associated to the Programme are committed. The Project focuses on the issue of different kinds of violence against women in rural areas.According to the World Health Organisation (WHO) it is estimated that 736 million women are victims of violence in intimate partner relationships or outside of them. The prevalence of domestic violence in developing countries among women aged between 15 and 49 is as high as 37% (WHO). Rural areas suffer the most from this problem. The consequences affect aspects such as mental and reproductive health, but, above all, human rights. The United Nations (UN) Sustainable Development Goals (SDGs) include Gender Equality and establish as a target the elimination of all forms of violence against women and girls.This problem has a very limited specific training offer and none from the Erasmus area. Our proposal aims to fill this gap by incorporating the specific territorial scope of rural areas as an innovative approach. The abandonment and marginalisation of the rural world has generated impoverishment and has accentuated economic and social problems.This project addresses a specific problem, violence against women in rural areas, proposing an innovative educational offer in line with the Erasmus+ priorities for the period 2021-2027: -Fostering social inclusion and diversity by tackling general obstacles, discrimination and vulnerability of women in rural areas through the design of a focus oriented academic offer within the framework of the EMJM.-Taking advantage of the institutional cooperation for addressing the topic of this proposal from an international perspective, removing geographical and discrimination barriers and boosting future sustainable development perspect

TraffikGene-Tx: Targeted and Dynamic RNA Peptide Vehicles -Unmet Clinical Need and Problem Rare and complex genetic diseases lead to significant disability, death and associated cost burdens for society. Complex genetic diseases include cardiovascular diseases (CVD) and cancer, the two leading causes of death in the EU and up to 36 million Europeans suffer from rare genetic diseases. Nucleic acid therapeutics (NATs) represent a potential treatment, but they are hampered by the “delivery problem.” Systemically administered naked RNA is quickly degraded by endonucleases, can provoke adverse immune reactions and has off-target toxicity. Viral and lipid nanoparticle (LNP) delivery vectors have toxic side-effects and are difficult to produce and target. -The Solution TraffikGene´s RNA delivery platform is: Safe: biodegradable, non-immunogenic peptide carriers that cleave to avoid the detergent toxicity of LNPs. Targetable: beyond the liver, to the spleen, lungs and heart with excellent delivery to the cytosol. Scalable: Production is automated, simple and cheap. TraffikGene combines modular design with high-throughput screening which will feed into AI-enhanced SAR-based predictive vehicle design. This will accelerate and de-risk NAT drug development. -The Project TraffikGene will capitalize on the current breakthroughs in healthcare represented by NATs. RNA therapeutics (mRNA, saRNA, siRNA, lncRNA, miRNA) are now emerging driven by the success of mRNA vaccines and TraffikGene will deliver them to the tissues where they are needed. We aim to break new ground in the field of RNA, validate our delivery vehicles and start developing our pipeline to advance to the preclinical trial stage with therapeutic RNAs. We aim to launch our company of customised peptide carriers for any RNA medicine with a proprietary flagship RNA-based immunotherapy. Our products will bring many promising NATs to the market, and help millions of patients, while reducing health care costs.

The forces governing the nano-biointeractions are essential to understand the biological behaviour and pharmacokinetics of the nanostructures. So far, these understandings have been limited to nanoparticles. However, it should be noted that the NPs´ chemical synthetic methods render non-homogeneous dispersions, even when low polydispersity is reached. In addition, the modification of NPs with a specific number of ligands is still challenging and there is no agreement about the most effective configuration or number of ligands to achieve efficient targeting in vivo. The programmability of the DNA-nanostructures (origamis) allows the synthesis of predictable and controllable sizes and shapes with almost atomic precision. In addition, the origamis can also be designed to include additional molecules, with high accuracy on the valency and the orientation. Thus, this technology offers a powerful tool to study and understand the biological behaviour of objects at the nanoscale since precise control over the size, shape and attachment of molecules can be achieved when other methods are unable to. Based on the structural organization and spatial distribution of natural and specific bionanoparticles, such as viruses, this project will exploit the atomic programmability of origamis to design a library of DNA nanostructures inspired on viral particles. The biomolecular corona will be studied to understand its impact on origamis´ biodistribution, a topic still not studied yet. Finally, the cell response will be evaluated in terms of targeting and immune response. These results will help to a better understanding of the mechanism between nano-structures and living systems and to formulate guidelines to synthesize more efficient nanomedicines. Overall, this project will allow me to carry out a 2-year project independently, growing towards a mature, professional and independent researcher in the DNA nanotechnology field, reinforcing my expertise on the nanomedicine field.

The Pierre Auger Observatory detects extensive air showers that are initiated by protons or nuclei reaching Earth's atmosphere with energies exceeding 10**18 eV (ultra-high energy cosmic rays (UHECR)). The center-of-mass energy of the initial interaction of the CRs in the atmosphere exceeds the energies reached at the LHC by more than an order of magnitude. One of the key results of Auger is the discovery that these interactions of UHECRs do not behave as expected. Compared to simulations the measured air showers contain many more muons. This discrepancy could be simply due to the uncertainty inherent in the extrapolation from the energy scale of the LHC, where we can measure interactions in detail, to UHECR energies. Or it could be new physics! This project proposes to distinguish the two scenarios by the detailed measurement of the shower-to-shower distribution of the muon content as the shape of the distribution is driven by the quantum fluctuations in the first UHE interaction which are sensitive to new physics and the details of hadronic interactions. The measurement will for the first time use hybrid data from the surface and radio detectors of the Pierre Auger Observatory.