The University of York (UoY) nuclear applications group is presently running a one-year GCRF project called NuTRAIN with University of Western Cape (UWC) and University of Zululand (UZ) in South Africa. They are transferring expertise in working with scintillators and silicon photomultipliers which can be applied to applications in environmental monitoring, experimental nuclear physics and medicine. Six South African students have visited York to receive training and funds have been provided to establish small detector development laboratories at UWC and UZ. The present MANDELA project intends to build on this initial training in the form of a genuine distributed project to develop the components for a new and inexpensive type of positron emission tomography (PET) scanner for medical imaging. This will be based on plastic scintillator and make use of a newly developed UK-based supply chain for plastic scintillator established by LabLogic, a company based in Sheffield close by to UoY. Students in South Africa will be trained to carry out GEANT4 simulations - a method that allows the response of radiation detectors to be studied and hence, novel detectors can be designed. Importantly, UoY will provide these simulations "in the cloud" avoiding the need for high performance computers based locally. The simulations could even be run on a web browser or on a smartphone. Based on the simulations, prototype detectors will be fabricated. Based on training received at York, the SA students will evaluate these and determine the best silicon photomultipliers and fibre optic configurations for scintillation light detection. The MANDELA project will provide funding to upgrade their detector laboratory so they can undertake the necessary work. The project will lead to a solid design for the basic components of a novel PET scanner which can be pursued through a further collaborative R&D phase or move rapidly to commercialisation.

Organic ion exchange resins are utilised in many different areas of the civil nuclear fuel cycle, from uranium ore concentration and refinement and chemical control of coolant water composition in light water reactors and spent fuel storage ponds, to decontamination of radioactive element-containing effluents arising from fuel reprocessing and nuclear decommissioning operations. These materials are effective "sponges" for a wide range of radioactive elements, hence their widespread use. The UK has stockpiled approximately 600 m3 of spent (i.e., used) ion exchange resins (SIERs), which require disposal, and continues to produce between 2.5 to 13 m3 per year. The disposal of SIERs is problematic; there are several key issues, which include: 1. The 14C inventory of the materials. This isotope has a half life of 5,730 years and is incorporated as 14CO32- and H14CO3-, which, if allowed to enter the environment are extremely mobile and biologically available. Release of 14C gas in a disposal environment provides a rapid 14C migration pathway to the biosphere; 2. The degradation of SIERs in a disposal environment through radioactive decay processes produces organic complexant molecules, which may facilitate rapid transport of radioactive elements from SIERs to the biosphere; 3. The degradation of SIERs in a storage environment may also yield chemically toxic gases such as benzene, phenol and ammonia, which make storage extremely problematic. These issues require the SIERs to be treated so as to meet waste acceptance criteria for disposal. This is typically achieved by destruction using thermal or chemical processes. In this proposal, we aim to develop a promising chemical treatment route for the destruction of SIERs, known as wet oxidation. Wet oxidation has been successfully trialled elsewhere for the destruction of non-radioactive surrogates for SIERs, however, the specific methods previously utilised do not give rise to by-product residues that are amenable to immobilisation in a material suitable for disposal in the UK. We propose two novel approaches to wet oxidation processes that will not only generate by-products more suitable for immobilisation, but that also have a greater destruction efficiency than those previously trialled. Furthermore, we will develop and optimise tailored cement, ceramic and glass waste forms for the immobilisation of SIER degradation. We will provide a robust scientific underpinning of the chemical speciation and local distribution of radionuclides in SIERs and the immobilisation matrices we develop, and understand their behaviour in disposal environments, to support the safe and timely disposal of SIER wastes. A significant novelty of this research is the verification of our new treatment and immobilisation methods for SIERs using real radioactive materials. After optimisation of the processes described above using inactive SIERs, we will apply them to real radioactive SIER from the UK decommissioning programme. If successful, this work will be a significant step towards demonstrating an effective treatment option for the resin, allowing early site termination of a significant hazard.

Most electrical equipment requires a power supply which usually incorporates a magnetic transformer to provide safety isolation and to step up or step down the input voltage. Piezoelectric transformers (PTs) offer an exciting alternative to conventional transformers particularly in applications requiring high power density, low electromagnetic interference and high temperature operation. Their widespread adoption is hindered, however, by the need for power supply designers to possess knowledge and training in both materials science and power electronics, combined expertise that is rarely found in industry or even academia. This lacking knowledge base represents a real impediment for power supply manufacturers who may wish to adopt PT technology and consequently PTs have only seen marginal market penetration. The project addresses these issues by producing a multi-physics design framework which provides abstraction from the fundamental science and therefore allows the design engineer to focus on the overall system design. The framework converts a high-level power supply specification into a PT power supply solution through a series of circuit and materials based transformations. An optimisation process (using evolutionary computing and finite element analysis) produces a fully characterised final design. The output of this process includes a circuit design and a "recipe" for the piezoelectric transformer, including materials and construction details presented in a format suitable for manufacture. The framework will be encapsulated in a user-friendly software design tool and validated against real-world power supply applications suggested by the project's industrial partners thereby ensuring the relevance of the research. The research, which will transcend the traditional barriers between electrical engineering and materials science, has an investigatory team with expertise in both areas. As well as developing a framework, the research will develop novel piezoelectric materials particularly suited to high temperature operation, finding promise in a number of application areas including aerospace, oil/gas exploration, electric vehicles and for remote monitoring in harsh environments. Additionally, the need for environmentally damaging lead-based PTs will be diminished through the development of new materials which comply with Restriction on Hazardous Substances 2016. The research programme will culminate in an open workshop where industry and academic researchers can learn about PT power supplies and evaluate the design tool for themselves. To ensure that the research remains industrially relevant we have partnered with several leading companies who will provide expertise and commercial drive and in return they will receive proof-of-concept power supplies ready for commercialisation.

"What is the Universe made of, and why?" Sheffield's HEP programme aims to address this fundamental question. There are two problems here: about 5/6 of the matter in the Universe seems to be an as yet undiscovered particle (dark matter), and the remaining 1/6 is all matter - not the 50:50 matter-antimatter mix we make in laboratories. We search for the dark matter particle in two ways: at the energy frontier, by seeking to detect new particles created by the high-energy proton-proton collisions of the LHC at CERN, and in direct searches, attempting to observe these particles in the Galaxy itself. The theory of supersymmetry, which predicts a whole set of particles related to, but more massive than, the known particles of the Standard Model (SM), offers a candidate dark matter particle. If supersymmetric particles can be made at the LHC, they should be detected in ATLAS. Our programme searches specifically for new Higgs bosons and for particles related to the SM quarks and gluons. At ATLAS, we also study SM processes involving the force carriers of the weak interaction, probing our understanding of the SM. Looking to the future, we are contributing essential work to the upgrade of the ATLAS experiment required to take full advantage of higher event rates in future running of the LHC. Most of the matter in our Galaxy is dark matter. In the LZ experiment, we search for evidence of dark matter colliding with Xe atoms in the experiment and causing them to recoil. This experiment will be the most sensitive dark matter detector ever constructed. Understanding possible background - non-dark-matter - events is critical to this, and we have world leading expertise in this field. In addition, we are leading the development of directional dark matter detectors, which will be vital in proving that any candidate signal really does come from the Galaxy and not the Earth. We are also the only UK group involved in the search for axions: another possible type of dark matter particle which cannot be detected at the LHC or in standard dark matter experiments. Why is the matter in the Universe all matter, not antimatter? The answer to this question must lie in subtle differences between particles and antiparticles, an effect called CP violation. The CP violating effects so far observed are not nearly large enough to create the Universe we see. The most likely source for more CP violation is in the interactions of neutrinos. A key observation is that neutrinos have mass, and that different types of neutrinos can interchange their identities in flight. The T2K experiment has made measurements of this, and has detected tantalising hints of CP violation. We plan to build on this work, both in running experiments (T2K and SBND) and in designing the next generation of neutrino experiments which will have much greater sensitivity. We have developed tools to assist the neutrino community in comparing results and improving our understanding of how neutrinos interact. Our access to Boulby Mine provides an invaluable low-background laboratory for testing materials and detector prototypes. Last but not least, we seek to apply HEP technology to industry and to solving global problems. We are using techniques developed for ATLAS to contribute to the development of robotics and to deal with highly radioactive environments such as Chernobyl. We are designing muon detectors to search for nuclear contraband and monitor volcanoes. Our signal processing techniques are being applied to improving medical imaging for heart patients. Our expertise in water Cherenkov neutrino detection is being exploited in an experiment designed to monitor compliance with nuclear non-proliferation treaties. All of this work builds on our STFC core programme to benefit the wider world.

Accelerate.EU, a collaborative European initiative, envisions revolutionising theranostics through innovative targeted alpha-therapies (TATs) using astatine-211. A unique consortium will combine diagnostics with potent cytotoxic effects of alpha-particles to enable precise tumour radiation while minimising side effects. Accelerate.EU's core objectives are: Innovate theranostic solutions based on therapeutic and diagnostic pairs for hard-to-treat cancers, exploring the potential for simultaneous preclinical studies and early-phase clinical trials (i.e. co-clinical approach) to showcase the enhanced benefits of these approaches for cancer patients. • Establish a robust and sustainable EU manufacturing and treatment infrastructure for astatine-211, ensuring compliance with quality assurance and regulatory guidelines while streamlining the supply chain across the EU. • Produce comprehensive educational and training content to support the deployment of theranostic solutions, fostering knowledge dissemination, transfer and longevity/durability Accelerate.EU strategically develop TATs to address unmet clinical needs in pancreatic, breast, and brain cancers. The co-clinical approach, incorporating concurrent clinical and preclinical studies, adds a breakthrough dimension to theranostics. Accelerate.EU pioneers 211At-theranostics establishing a resilient EU scale-up production network and empowering healthcare providers to offer TATs to cancer patients. Through the collaboration of experts from academia, industry and regulatory agencies, Accelerate.EU's implements a visionary approach addressing clinical gaps, accelerating TAT theranostic development, supporting EU global leadership, with primary target to improve patient outcomes for lasting impact on EU cancer care.