The WELL CARE project aims to strengthen supports available to long-term care (LTC) workers and informal carers for improving their resilience and mental well-being through care partnerships. The WELL CARE project has four specific objectives for these target groups: 1) To review, organise and make available evidence and data (with a focus on gender, inclusion, occupation and non-occupation specific factors) on how to best support resilience and mental well-being: we will identify and analyse 40 good practices and perform 10 in-depth case studies; 2) To identify, evaluate and promote the adoption of innovative solutions and prototypes: we will develop 5-8 general solution prototypes, which will be implemented and tested with interested stakeholders (e.g., LTC providers and employers) in five European Union countries (Germany, Italy, Netherlands, Slovenia, Sweden). We will provide resources, guidance and a helpdesk to sustain implementation and the creation of favourable local, regional and national ecosystems; 3) To develop and foster evidence-based and action-oriented recommendations for policy makers and stakeholders: we will analyse the policy, legislative, service and financing frameworks, also elaborating recommendations on the basis of data and evidence generated by the project; 4) To develop, implement and sustain a continuous process of research and co-design activities with end-users and stakeholders at national level: we will set up and implement Blended Learning Networks, establishing a participatory research design and addressing real needs and perspectives from the target groups. The WELL CARE project will positively impact LTC workers’ and informal carers’ mental health and productivity (micro-level), as well as providing LTC providers with new solutions and tools for effective, efficient and sustainable support and retainment of the care workforce (meso-level) and new data and recommendations for policy makers and stakeholders (macro-level).

The ZikaPLAN initiative combines the strengths of 25 partners in Latin America, North America, Africa, Asia, and various centres in Europe to address the urgent research gaps (WP 1-8) in Zika, identifying short-and long term solutions (WP 9-10) and building a sustainable Latin-American EID Preparedness and Response capacity (WP 11-12). We will conduct clinical studies to further refine the full spectrum and risk factors of congenital Zika syndrome (including neurodevelopmental milestones in the first 3 years of life), and delineate neurological complications associated with Zika due to direct neuroinvasion and immune-mediated responses. Laboratory based research to unravel neurotropism, investigate the role of sexual transmission, determinants of severe disease, and viral fitness will envelop the clinical studies. Burden of disease and modelling studies will assemble a wealth of data including a longitudinal cohort study of 17,000 subjects aged 2-59 in 14 different geographic locations in Brazil over 3 years. Data driven vector control and vaccine modelling as well as risk assessments on geographic spread of Zika will form the foundation for evidence-informed policies. The Platform for Diagnostics Innovation and Evaluation will develop novel ZIKV diagnostic tests in accordance with WHO Target Product Profiles. Our global network of laboratory and clinical sites with well-characterized specimens is set out to accelerate the evaluation of the performance of such tests. Based on qualitative research, we will develop supportive, actionable messages to affected communities, and develop novel personal protective measures. Our final objective is for the Zika outbreak response effort to grow into a sustainable Latin-American network for emerging infectious diseases research preparedness. To this end we will engage in capacity building in laboratory and clinical research, collaborate with existing networks to share knowledge and tackle regulatory and other bottlenecks.

Five years ago, a global infrastructure to uniquely attribute to researchers their scientific artefacts (articles, data, software…) appeared technically and socially infeasible. Since then, DataCite has minted over 3.5m unique identifiers for data. ORCID has deployed an open solution for identification of contributors with over 850,000 registrants in less than 2 years. THOR will leverage these emerging global infrastructures to support the H2020 goal to make every researcher ‘digital’ and increase creativity and efficiency of research, while bridging the R&D divide between developed and less-developed regions. We will establish interoperability between existing resources, linking digital identifiers across platforms and propagating attribution information. We will integrate PID services across the research lifecycle and data publishing workflows in four advanced research communities, and then roll-out core services and service building blocks for the wider community. These open resources will foster an open and sustainable e-infrastructure across stakeholders to avoid duplications, give economies of scale, richness of services and the ability to respond rapidly to opportunities for innovation. THOR is not just relevant to the EINFRA-7-1024 Call, but will become a pervasive element of the EINFRA family of e-Infrastructure resources over the next 3 years. It will allow data-management and curation services to exploit knowledge of data location and attribution; provide robust and persistent mechanism for linking literature and data; enable search and resolving services and generate incentives for Open Science; deliver provenance and attribution mechanisms to underpin data exchange; and provide minting and resolving services for data citation workflows. Its impact will enable third-party services, no-profit and commercial, to leverage the scholarly record.