COMPARE aims to harness the rapid advances in molecular technology to improve identification and mitigation of emerging infectious diseases and foodborne outbreaks. To this purpose COMPARE will establish a “One serves all” analytical framework and data exchange platform that will allow real time analysis and interpretation of sequence-based pathogen data in combination with associated data (e.g. clinical, epidemiological data) in an integrated inter-sectorial, interdisciplinary, international, “one health” approach. The framework will link research, clinical and public health organisations active in human health, animal health, and food safety in Europe and beyond, to develop (i) integrated risk assessment and risk based collection of samples and data, (ii) harmonised workflows for generating comparable sequence and associated data, (iii) state-of-the-art analytical workflows and tools for generating actionable information for support of patient diagnosis, treatment, outbreak detection and -investigation and (iv) risk communication tools. The analytical workflows will be linked to a flexible, scalable and open-source data- and information platform supporting rapid sharing, interrogation and analysis of sequence-based pathogen data in combination with other associated data. The system will be linked to existing and future complementary systems, networks and databases such as those used by ECDC, NCBI and EFSA. The functionalities of the system will be tested and fine tuned through underpinning research studies on priority pathogens covering healthcare-associated infections, food-borne disease, and (zoonotic) (re-) emerging diseases with epidemic or pandemic potential. Throughout the project, extensive consultations with future users, studies into the barriers to open data sharing, dissemination and training activities and studies on the cost-effectiveness of the system will support future sustainable user uptake.

Thermosetting Polyurethanes (PU) provide a unique combination of durability, light weight, high strength and flexibility to high value consumer goods and other applications. PU thermosets have grown to a global market of 50 billion €, ultimately resulting in high volumes of waste mostly disposed via landfill or incineration as the SOA of the recycling technology is limited. PUReSmart will bridge the gap between the current PU linear economy to a circular model by designing smart polyurethane materials that can be reshaped into new products with undiminished quality. PUReSmart will provide solutions for the identified three scientific-technological urgent needs that require conceptual breakthroughs: 1) Smart DESIGN of covalent adaptable polyurethanes (CAPU) to bridge the gap between thermosets and thermoplastics, thanks to thermally reversible bonds; these CAPU are reprocessable, similarly to thermoplastics. 2) Smart SORTING, using the unique spectroscopic fingerprints of conventional PU and smart building blocks to create a validated and cost effective PU sorting platform with high specificity and sensitivity; this enables driving CAPUs to reprocessing and PU to chemolysis. 3) Smart CHEMOLYSIS with mass balanced and minimized input of virgin chemicals, maximal purity and efficient isolation of the obtained building blocks resulting in full re-utilization of all obtained fractions for PU or CAPUs; PUReSmart will integrate CAPU chemistry with monomers obtained by next-generation chemolysis processes, using well-sorted feedstocks, aiming at scalable industrial products (TRL 5) with social and economic value assessed by a Life Cycle Analysis for ‘cyclic’ PU. The project encompasses a concerted effort of partners along the value- and revalorization chain: PU producers, producers of the building blocks, technology providers for physical sorting, and research institutions focusing on design of new PU types and on innovative chemolysis methods for existing PU types.

Manufacturers of automated systems and the manufacturers of the components used in these systems have been allocating an enormous amount of time and effort in the past years developing and conducting research on automated systems. The effort spent has resulted in the availability of prototypes demonstrating new capabilities as well as the introduction of such systems to the market within different domains. Manufacturers of these systems need to make sure that the systems function in the intended way and according to specifications which is not a trivial task as system complexity rises dramatically the more integrated and interconnected these systems become with the addition of automated functionality and features to them. With rising complexity, unknown emerging properties of the system may come to the surface making it necessary to conduct thorough verification and validation (V&V) of these systems. VALU3S aims to design, implement and evaluate state-of-the-art V&V methods and tools in order to reduce the time and cost needed to verify and validate automated systems with respect to safety, cybersecurity and privacy (SCP) requirements. This will ensure that European manufacturers of automated systems remain competitive and that they remain world leaders. To this end, a multi-domain framework is designed and evaluated with the aim to create a clear structure around the components and elements needed to conduct V&V process through identification and classification of evaluation methods, tools, environments and concepts that are needed to verify and validate automated systems with respect to SCP requirements. The implemented V&V methods as well as improved process workflows and tools will also be evaluated in the project using a comprehensive set of demonstrators built from 13 use cases with specific SCP requirements from 6 domains of automotive, industrial robotics, agriculture, Aerospace, railway and health.