BindingDB Entry 50042664: Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.

Name: BindingDB Entry 50042664: Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
Creator: BindingDB
Keywords: Acyl Cholesterol Acyltransferase 1 (ACAT-1), Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2), Cytochrome P450 3A, Diacylglycerol O-acyltransferase 1 (DGAT1), and Diacylglycerol O-acyltransferase 2, Merck Research Laboratories, Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2013 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2sx6fjw

BindingDB Entry 50042664: Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.

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Abstract

Small molecule binding data for protein Acyl Cholesterol Acyltransferase 1 (ACAT-1), Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2), Cytochrome P450 3A, Diacylglycerol O-acyltransferase 1 (DGAT1), and Diacylglycerol O-acyltransferase 2, Uniprot O75907, O75908, P08684, P35610, and Q96PD7

Keywords

Acyl Cholesterol Acyltransferase 1 (ACAT-1), Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2), Cytochrome P450 3A, Diacylglycerol O-acyltransferase 1 (DGAT1), and Diacylglycerol O-acyltransferase 2, Merck Research Laboratories, Affinity

16 Research products, page 1 of 2

BindingDB Entry 50043288: Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.
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BindingDB Entry 50011105: Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome.
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BindingDB Entry 3097: Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor.
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BindingDB Entry 50044217: Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.
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BindingDB Entry 2850: Tricyclic analogues, preparation method and uses thereof
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Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors
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BindingDB Entry 50042696: Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.
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BindingDB Entry 50044111: Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents.
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BindingDB Entry 50040765: Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).
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BindingDB Entry 7238: Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease
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