BindingDB Entry 8042: Inhibitors of protein tyrosine phosphatases

Name: BindingDB Entry 8042: Inhibitors of protein tyrosine phosphatases
Creator: BindingDB

Research datakeyboard_double_arrow_right Dataset 01 Jan 2017 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2nv9h4j

BindingDB Entry 8042: Inhibitors of protein tyrosine phosphatases

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Abstract

Small molecule binding data for protein Dual specificity protein phosphatase (VHR), Dual specificity protein phosphatase VHX (VHX), Fas-associated protein-tyrosine phosphatase 1 (FAP1), Hematopoietic protein-tyrosine phosphatase (HEPTP), Laforin, Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2), Protein tyrosine phosphatase SHP-2 (SHP-2), Protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1B, Protein-tyrosine phosphatase 1C, Receptor-type tyrosine-protein phosphatase F (LAR), Receptor-type tyrosine-protein phosphatase beta (PTPβ), Receptor-type tyrosine-protein phosphatase epsilon (PTPε), Receptor-type tyrosine-protein phosphatase gamma (PTPγ), Receptor-type tyrosine-protein phosphatase mu (PTPμ), T-cell protein-tyrosine phosphatase, Tyrosine-Protein Phosphatase (CD45), Tyrosine-protein phosphatase non-receptor type 12 (PTP-PEST), Tyrosine-protein phosphatase non-receptor type 22, Tyrosine-protein phosphatase non-receptor type 3 (PTPH1), and Tyrosine-protein phosphatase non-receptor type 9 (PTP-MEG2), Uniprot O95278, P08575, P10586, P17706, P18031, P23467, P23469, P23470, P26045, P28827, P29074, P29350, P35236, P51452, Q05209, Q06124, Q12913, Q12923, Q9NRW4, and Q9Y2R2

Keywords

Dual specificity protein phosphatase (VHR), Dual specificity protein phosphatase VHX (VHX), Fas-associated protein-tyrosine phosphatase 1 (FAP1), Hematopoietic protein-tyrosine phosphatase (HEPTP), Laforin, Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2), Protein tyrosine phosphatase SHP-2 (SHP-2), Protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1B, Protein-tyrosine phosphatase 1C, Receptor-type tyrosine-protein phosphatase F (LAR), Receptor-type tyrosine-protein phosphatase beta (PTPβ), Receptor-type tyrosine-protein phosphatase epsilon (PTPε), Receptor-type tyrosine-protein phosphatase gamma (PTPγ), Receptor-type tyrosine-protein phosphatase mu (PTPμ), T-cell protein-tyrosine phosphatase, Tyrosine-Protein Phosphatase (CD45), Tyrosine-protein phosphatase non-receptor type 12 (PTP-PEST), Tyrosine-protein phosphatase non-receptor type 22, Tyrosine-protein phosphatase non-receptor type 3 (PTPH1), and Tyrosine-protein phosphatase non-receptor type 9 (PTP-MEG2), Indiana University Research and Technology Corporation, Affinity

14 Research products, page 1 of 2

BindingDB Entry 50046441: Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
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BindingDB Entry 50009067: PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.
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BindingDB Entry 50030635: Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
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BindingDB Entry 50009694: Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions.
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BindingDB Entry 50043122: A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.
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BindingDB Entry 50031153: Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
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BindingDB Entry 50045878: Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.
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BindingDB Entry 50011052: Highly Potent and Selective
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BindingDB Entry 50012571: Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.
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BindingDB Entry 50043434: Calix[4]arene methylenebisphosphonic acids as inhibitors of protein tyrosine phosphatase 1B.
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