BindingDB Entry 50018938: Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon.

Name: BindingDB Entry 50018938: Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon.
Creator: BindingDB
Keywords: Acyl Cholesterol Acyltransferase 1 (ACAT-1) and Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2), National Research Laboratory of Lipid Metabolism and Atherosclerosis, Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2009 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2h70ffw

BindingDB Entry 50018938: Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon.

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Abstract

Small molecule binding data for protein Acyl Cholesterol Acyltransferase 1 (ACAT-1) and Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2), Uniprot O75908 and P35610

Keywords

Acyl Cholesterol Acyltransferase 1 (ACAT-1) and Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2), National Research Laboratory of Lipid Metabolism and Atherosclerosis, Affinity

16 Research products, page 1 of 2

BindingDB Entry 50042918: Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.
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BindingDB Entry 50043120: Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.
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BindingDB Entry 50015116: Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size.
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BindingDB Entry 50003084: Discovery of Clinical Candidate 2-(4-(2-((1 H-Benzo[ d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor.
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BindingDB Entry 50043106: Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo.
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BindingDB Entry 50042664: Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
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BindingDB Entry 50017135: Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors.
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