BindingDB Entry 50031183: Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.

Name: BindingDB Entry 50031183: Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.
Creator: BindingDB
Keywords: 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) and 11-beta-hydroxysteroid dehydrogenase 2, Vienna University of Technology, Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2010 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2bp02w3

BindingDB Entry 50031183: Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.

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Abstract

Small molecule binding data for protein 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) and 11-beta-hydroxysteroid dehydrogenase 2, Uniprot P16232 and P50233

Keywords

11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) and 11-beta-hydroxysteroid dehydrogenase 2, Vienna University of Technology, Affinity

20 Research products, page 1 of 2

Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases
2010IsDerivedFrom
BindingDB Entry 50033116: Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11ß-hydroxysteroid dehydrogenase 2 inhibitors.
2011IsAmongTopNSimilarDocuments
BindingDB Entry 50043078: Evaluation of selective inhibitors of 11ß-HSD1 for the treatment of hypertension.
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BindingDB Entry 50027771: Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.
2010IsAmongTopNSimilarDocuments
BindingDB Entry 5865: Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
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BindingDB Entry 50042936: Discovery of SAR184841, a potent and long-lasting inhibitor of 11ß-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.
2014IsAmongTopNSimilarDocuments
BindingDB Entry 50043187: Mono-carbonyl curcumin analogues as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.
2014IsAmongTopNSimilarDocuments
Higher 11-beta-hydroxysteroid dehydrogenase type I gene expression in white adipose tissue in male than female rats.
2012IsAmongTopNSimilarDocuments
BindingDB Entry 50018414: Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome.
2009IsAmongTopNSimilarDocuments
BindingDB Entry 3391: Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
2009IsAmongTopNSimilarDocuments

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