BindingDB Entry 50033297: 2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors.

Name: BindingDB Entry 50033297: 2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors.
Creator: BindingDB
Keywords: ADAM17, Collagenase, Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), Matrix metalloproteinase-1 (MMP1), Matrix metalloproteinase-14 (MMP14), Matrix metalloproteinase-7 (MMP7), and Stromelysin-1, Merck Research Laboratories, Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2011 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q28p60t1

BindingDB Entry 50033297: 2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors.

- Summary
- Subjects
- Related research
  (18)
- Metrics

tips_and_updates
Recommended

Abstract

Small molecule binding data for protein ADAM17, Collagenase, Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), Matrix metalloproteinase-1 (MMP1), Matrix metalloproteinase-14 (MMP14), Matrix metalloproteinase-7 (MMP7), and Stromelysin-1, Uniprot O14672, P03956, P08253, P08254, P09237, P14780, P45452, P50281, and P78536

Keywords

ADAM17, Collagenase, Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), Matrix metalloproteinase-1 (MMP1), Matrix metalloproteinase-14 (MMP14), Matrix metalloproteinase-7 (MMP7), and Stromelysin-1, Merck Research Laboratories, Affinity

18 Research products, page 1 of 2

BindingDB Entry 7111: N-[2-hydroxycarbamoyl-2-(piperazinyl) ethyl] benzamide compounds, their preparation and their use as TACE inhibitors
2016IsAmongTopNSimilarDocuments
BindingDB Entry 50030219: Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket.
2010IsAmongTopNSimilarDocuments
2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors
2011IsDerivedFrom
BindingDB Entry 50000241: Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors.
2019IsAmongTopNSimilarDocuments
BindingDB Entry 50015483: Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors.
2009IsAmongTopNSimilarDocuments
BindingDB Entry 50043441: TBA
2014IsAmongTopNSimilarDocuments
BindingDB Entry 50002122: Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis.
2020IsAmongTopNSimilarDocuments
BindingDB Entry 7641: 4-alkoxy-N-(2-hydroxycarbamoyl-2-piperidinyl-ethyl)-benzamide compounds as selective TACE-inhibitors for the treatment of inflammatory diseases
2017IsAmongTopNSimilarDocuments
BindingDB Entry 50031468: Discovery and SAR of hydantoin TACE inhibitors.
2010IsAmongTopNSimilarDocuments
BindingDB Entry 50001770: In Search of Selectivity in Inhibition of ADAM10.
2020IsAmongTopNSimilarDocuments

chevron_left
1
2
chevron_right

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average