BindingDB Entry 10841: Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors

Name: BindingDB Entry 10841: Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
Creator: BindingDB
Keywords: Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, and cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A, ELI LILLY AND COMPANY, Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2022 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q22z18rf

BindingDB Entry 10841: Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors

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Abstract

Small molecule binding data for protein Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, and cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A, Uniprot P16499, P35913, P54750, Q01064, Q08499, Q14123, and Q14432

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University of California, San Diego
United States

Keywords

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, and cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A, ELI LILLY AND COMPANY, Affinity

13 Research products, page 1 of 2

BindingDB Entry 10730: [1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes
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BindingDB Entry 10946: 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
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BindingDB Entry 9682: Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors
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BindingDB Entry 9936: 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
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BindingDB Entry 50015108: Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.
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BindingDB Entry 10329: [1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives
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BindingDB Entry 50029923: TBA
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BindingDB Entry 9064: Macrocycles as PDE1 inhibitors
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BindingDB Entry 50016551: Discovery of hydroxamic acid analogs as dual inhibitors of phosphodiesterase-1 and -5.
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